219
Views
0
CrossRef citations to date
0
Altmetric
CASE REPORT

Multiply Relapsed Secondary CNS Non-Germinal Center Diffuse Large B-Cell Lymphoma Successfully Treated with CNS-Centric Therapy

ORCID Icon, , ORCID Icon, , , ORCID Icon & ORCID Icon show all
Pages 455-461 | Received 21 Jan 2023, Accepted 16 Jul 2023, Published online: 16 Aug 2023

Figures & data

Figure 1 MRI Imaging at Second Relapse. Contrast enhanced axial MRI showing infiltrative, multifocal, enhancing mass lesions with one of the larger components centered within the splenium of the corpus callosum.

Figure 1 MRI Imaging at Second Relapse. Contrast enhanced axial MRI showing infiltrative, multifocal, enhancing mass lesions with one of the larger components centered within the splenium of the corpus callosum.

Figure 2 Pathologic Evaluation of the Left Parietal Tumor. H&E x40 magnification shows large B cells (A). IHC x20 magnification shows that the neoplastic B-cells stained positive for CD20 (B), BCL6 (C), BCL2 (D), MUM1 (E) with a high MIB1 proliferation rate (F).

Abbreviations: H&E, haematoxylin and eosin; IHC, immunohistochemistry.
Figure 2 Pathologic Evaluation of the Left Parietal Tumor. H&E x40 magnification shows large B cells (A). IHC x20 magnification shows that the neoplastic B-cells stained positive for CD20 (B), BCL6 (C), BCL2 (D), MUM1 (E) with a high MIB1 proliferation rate (F).

Figure 3 MRI Imaging Post-Treatment. (A and B) MRI after salvage therapy with near complete remission. (C) Repeat contrast enhanced MRI following day 100 work-up status post second ASCT shows complete remission.

Abbreviations: ASCT, autologous stem cell transplant; MRI, magnetic resonance imaging.
Figure 3 MRI Imaging Post-Treatment. (A and B) MRI after salvage therapy with near complete remission. (C) Repeat contrast enhanced MRI following day 100 work-up status post second ASCT shows complete remission.

Table 1 Case Presentation Treatment Summary

Table 2 Summary of Clinical Trials in SCNSL and Reported Outcomes