Acquired hemophilia A: emerging treatment options

Figures & data

Table 1 Underlying conditions associated with AHA

Pregnancy

Autoimmune diseases

• Systemic lupus erythematosus

• Rheumatoid arthritis

• Multiple sclerosis

• Dermatologic conditions (eg, psoriasis, pemphigus vulgaris)

• Temporal arteritis

• Sjögren syndrome

• Inflammatory bowel disease

• Goodpasture syndrome

• Graft-versus-host disease

• Myasthenia gravis

• Graves’ disease

• Autoimmune hemolytic anemia

• Autoimmune hypothyroidism

Underlying malignancy

• Hematologic malignancy (eg, chronic lymphocytic leukemia, non-Hodgkin lymphoma, multiple myeloma, Waldenström macroglobulinemia)

• Solid organ tumors (eg, lung, prostate, pancreas, breast)

Medications

• Antibiotics (eg, penicillin, sulfonamides)

• Others (eg, phenytoin, chloramphenicol, methyldopa, interferon alpha, fludarabine)

Acute hepatitis B and C infections

Respiratory disease (eg, asthma, chronic obstructive pulmonary disease)

Note: Data from Toschi and Baudo³ and Sborov and Rodgers.¹⁸

Abbreviation: AHA, acquired hemophilia A.

Figure 1 Bleeding associated with acquired hemophilia A.

Note: Extensive ecchymosis of the arms is visible.

Figure 2 Regimen for combined sequential bypassing therapy.

ToschiVBaudoFDiagnosis, laboratory aspects and management of acquired hemophilia AIntern Emerg Med20105432533320407848

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SborovDWRodgersGMAcquired hemophilia a: a current review of autoantibody diseaseClin Adv Hematol Oncol2012101192722398803

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