Relationship between HMGB1 and PAI-1 after allogeneic hematopoietic stem cell transplantation

Figures & data

Table 1 Levels of HMGB1 and PAI-1 before and after aHSCT

Time of measurementa	HMGB1		PAI-1
	Level (ng/mL)	P-value	Level (ng/mL)	P-value
Day −7	7.6±2.2	–	15.3±5.5	–
Day 0	12.2±2.6	<0.001	16.7±6.1	NS
Day 4	10.3±3.1	<0.01	16.9±6.3	NS
Day 7	8.7±2.2	NS	17.4±5.8	NS
Day 14	7.4±2.3	NS	18.2±7.5	<0.05
Day 21	7.0±2.1	NS	19.5±7.3	<0.01
Day 28	6.6±2.5	NS	21.7±7.7	<0.01

Notes: Data are shown as the mean ± SD. Values are compared with those from day 7.

a Time of measurement is shown before and after aHSCT. –, indicates no entry.

Abbreviations: NS, not significant; HMGB1, high-mobility group box 1; PAI-1, plasminogen activator inhibitor-1; aHSCT, allogeneic hematopoietic stem cell transplantation; SD, standard deviation.

Figure 1 The comparison of HMGB1 levels.

Note: Data are shown as means ± SD.
Abbreviations: TBI, total body irradiation; CY, cyclophosphamide; Flu, fludarabine; Bu, busulfan; BMT, bone marrow transplantation; PBSCT, peripheral blood stem cell transplantation; CBT, cord blood transplantation; Cys, cyclosporine; FK, tacrolimus; NS, not significant; HMGB1, high-mobility group box 1; SD, standard deviation.

Figure 2 Changes in PAI-1 levels following aHSCT conditioning regimens with and without significant elevation in HMGB1.

Notes: Group A: HMGB1 levels >1.5-fold higher than baseline. Group B: HMGB1 levels <1.5-fold higher than baseline. *P-values are for comparison with each baseline parameter (before vs day 0, 4, 7, 14, 21, or 28); **Group A vs Group B.
Abbreviations: PAI-1, plasminogen activator inhibitor-1; aHSCT, allogeneic hematopoietic stem cell transplantation; HMGB1, high-mobility group box 1; NS, not significant.