Antidiabetic and gastric emptying inhibitory effect of herbal Melia azedarach leaf extract in rodent models of diabetes type 2 mellitus

Figures & data

Figure 1 Antidiabetic effects of graded intraperitoneal dose effect of Melia azedarach aqueous leaf extracts (200, 300, and 400 mg/kg) on plasma glucose level in ob/ob mice over a period of 4 h.

Notes: Results were expressed as mean ± standard error. *p<0.05, **p<0.01, and ***p<0.001.

Figure 2 Long-term effect of Melia azedarach aqueous leaf extract (200 or 400 mg/kg) or glibenclamide (5 mg/kg) on plasma glucose (A) and insulin (B) levels in ob/ob mice over a study period of 3 weeks.

Notes: Results are expressed as mean ± standard error. **p<0.01, ***p<0.001.

Figure 3 Intraperitoneal glucose tolerance test on ob/ob mice treated with (A) Melia azedarach leaf extract (200 mg/kg), (B) M. azedarach leaf extract (400 mg/kg), and (C) glibenclamide (5 mg/kg) before and after a treatment period of 3 weeks.

Notes: Results are expressed as mean ± standard error. *p<0.05, ** p<0.01. Two tests were done with an interval of 3 weeks; each test covers a 180 min period.

Figure 4 Effects of Melia azedarach aqueous leaf extract on gastric emptying rates in Sprague-Dawley (SD) and Goto-Kakizaki (GK) rats.

Notes: Results are expressed as mean ± standard error. ***p<0.001.