Antidiabetic Effect of Germinated Lens culinaris Medik Seed Extract in Streptozotocin-Induced Diabetic Mice

Figures & data

Figure 1 Effect of extract on body weight in diabetic mice.

Note: Data expressed as means ± SEM (n=5).

Abbreviations: Ext.100, 100 mg/kg extract; Ext.200, 200 mg/kg extract; Ext.400, 400 mg/kg extract; GC5, glibenclamide 5 mg/kg; NC, normal control; DC, diabetic control.

Figure 2 Effect of extract on blood-glucose levels in normal mice.

Note: Data expressed as means ± SEM (n=5).

Abbreviations: Ext.100, 100 mg/kg extract; Ext.200, 200 mg/kg extract; Ext.400, 400 mg/kg extract; GC5, glibenclamide 5 mg/kg; NC, normal control.

Figure 3 Effect of extraction oral glucose tolerance in normal mice.

Note: Data expressed as means ± SEM (n=5).

Abbreviations: Ext.100, 100 mg/kg extract; Ext.200, 200 mg/kg extract; Ext.400, 400 mg/kg extract; GC5, glibenclamide 5 mg/kg; NC, normal control.

Table 1 Effects of Extract on Blood Glucose Level in Diabetic Mice

Groups (n=5)	Fasting Blood Glucose Level (mg/dL), Mean +SEM
	0 Day	7th Day	14th Day	21st Day
Normal control (vehicle)	96.33±5.27	97.17±3.66	95.17±2.69	97.5±3.80
DM control (vehicle)	244.17±6.35^n	248.5±5.38^n	251.17±5.14^n	252.17±3.84^n
DM + glibenclamide 5 mg/kg	250±5.51^n	151.83±1.51^n,a,b,c,d	147±1.15^n,a,b,c,d	141.17±1.22^n,a,b,c,d
DM + extract 100 mg/kg	249.83±7.14^n	207.67±1.86^n,a	198.57±2.73^n,a	190.83±1.80^n,a
DM + extract 200 mg/kg	246±4.74^n	194.33±4.42^n,a	187.1±2.62^n,a	180.83±2.858^n,a
DM + extract 400 mg/kg	241±4.34^n	180.5±0.92^n,a,b	175±1.69^n,a,b	169.92±1.62^n,a,b

Notes: ⁿp<0.05 compared with normal control; ^ap<0.05 compared with diabetic control; ^bp<0.05 compared with 100 mg/kg extract; ^cp<0.05 compared with 200 mg/kg extract; ^dp<0.05 compared with 400 mg/kg extract.

Table 2 Effect of Extract on Lipid Profile in Diabetic Mice

Groups (n=5)	TG (mg/dL), Mean ± SEM	TC (mg/dL), Mean ± SEM	VLDL (mg/dL), Mean ± SEM
Normal control	55.83±1.68	68±1.29	11.17±0.34
Diabetic control	184±1.73^n	170±2.91^n	36.8±0.35^n
DM + glibenclamide 5 mg/kg	58±0.73^a,b	79.83±1.25^n,a,b,c	11.6±0.15^a,b
DM + extract 100 mg/kg	69.17±1.66^n,a	98.67±2.39^n,a	13.83+0.33^n,a
DM + extract 200 mg/kg	64±1.65^n,a	90.17±1.47^n,a	12.8±0.33^n,a
DM + extract 400 mg/kg	60±1.44^a,b	87.83±2.15^n,a,b	12±0.29^a,b

Notes: ⁿp<0.05 compared with normal control; ^ap<0.05 compared with diabetic control; ^bp<0.05 compared with 100 mg/kg extract; ^cp<0.05 compared with 200 mg/kg extract.