Multiple Pathway–Mediated Gut-Modulatory Effects of Maerua subcordata (Gilg) DeWolf

Figures & data

Table 1 Antidiarrheal Activity of Crude Extract of Maerua Subcordata Leaves (MSL.Cr) in Mice with Castor Oil (10 mL/kg)–Induced Diarrhea

Treatment (Oral) Dose (mg/kg)	Mice with Diarrhea	% Protection
Saline (10 mL/kg) + castor oil	5/5	0
MSL.Cr (500 mg/kg) + castor oil	3/5^a	40
MSL.Cr (1,000 mg/kg) + castor oil	1/5^a	80
Loperamide(10 mg/kg) + castor oil	0/5 ^b	100

a Note: ^aP<0.05 and ^bP<0.01 vs saline + castor oil–treated group (χ²-test).

Figure 1 Effects of a crude extract of Maerua subcordata leaves (MSL.Cr) on the contraction of isolated rabbit jejunal preparations, both in the absence (■) and presence (▲) of atropine (0.1 µM). Results presented as percentage change compared to control and data as means ± SEM from four to five determinations.

Figure 2 Concentration–response curves showing the inhibitory effect of a crude extract of Maerua subcordata leaves (MSL.Cr) (A) and verapamil (B), against carbachol (CCh 1 µM), low (25 mM), and high (80 mM) K⁺-induced contractions in isolated rabbit jejunal preparations. Results presented as percentage change compared to control and data as means ± SEM, n=3–5.

Figure 3 Inhibitory concentration–response curves of isoprenaline against carbachol-induced contractions in the absence and presence of different concentrations of a crude extract of Maerua subcordata leaves (MSL.Cr) (A), papaverine (B), and verapamil (C) in isolated rabbit jejunum preparations. Values shown as means ± SEM from four to five determinations.

Figure 4 Concentration–response curves showing inhibitory effect of a crude extract of leaves of Maerua subcordata (MSL.Cr) against low K⁺ (25 mM)–induced contractions in the absence and presence of pretreated preparations with Gb (10 µM) and TEA (10 mM) in isolated rabbit jejunal preparations. Values shown as means ± SEM, n=3–5.