Figures & data
Table 1 Calcium absorbability from calcium salts measured by mass balance method
Table 2 Pharmacokinetic parameters of calcium in mice after IV or oral administration of calcium chloride, calcium acetate, or calcium ascorbate
Table 3 Pharmacokinetic parameters of calcium in female mice after IV or oral administration of calcium
Figure 1 Time course of plasma calcium concentrations after intravenous calcium administration of 15 mg/kg or 30 mg/kg of body weight of calcium L-lactate.
Notes: (A) Open circles refer to plasma calcium concentrations after administration of 30 mg/kg of body weight, closed circles refer to calcium administration of 15 mg/kg of body weight, and open squares are the plasma calcium concentrations of the control mice. (B) In total, 150 mg/kg of body weight of calcium L-lactate in 1% solution was orally delivered to the duodenum and blood was collected. Open circles refer to plasma calcium concentrations after oral administration of one of the three calcium salts, and open squares are the plasma calcium concentrations of the control mice. Data points represent the mean ± standard deviation (n = 4).
Abbreviation: n, number.
Abbreviation: n, number.
Figure 2 Effect of the foods DFA III, sudachi juice, and moromi-su on the absolute bioavailability of calcium of 150 mg/kg from CaCl2.
Notes: (A) CaCl2 + DFA III; (B) CaCl2 + sudachi juice; and (C) CaCl2 + moromi-su. CaCl2 + food means that food was orally administered, following oral administration of 150 mg of calcium per kg from CaCl2, and blood samples were collected. Closed circles refer to plasma calcium concentrations after oral administration of food and calcium chloride, and open circles are the plasma calcium concentrations after oral administration of CaCl2. Data points represent the mean ± standard deviation (n = 4).
Abbreviations: DFA III, di-D-fructo-furanose-1,2′:2,3′-dianhydride; CaCl2, calcium chloride; n, number.
Abbreviations: DFA III, di-D-fructo-furanose-1,2′:2,3′-dianhydride; CaCl2, calcium chloride; n, number.
Table 4 Effect of foods on pharmacokinetic parameters of calcium in male mice after oral administration of calcium chloride