114
Views
0
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

Beta2-Microglobulin as Predictive Biomarkers in the Prognosis of Hepatocellular Carcinoma and Development of a New Nomogram

ORCID Icon, , , , ORCID Icon, , , & ORCID Icon show all
Pages 1813-1825 | Received 29 Jun 2023, Accepted 04 Oct 2023, Published online: 11 Oct 2023

Figures & data

Figure 1 The flow of study.

Abbreviations: HCC, hepatocellular carcinoma; HR, hazard ratio; CI, confidence interval; β2MG, beta2-microglobulin; ROC, receiver operating characteristic.
Figure 1 The flow of study.

Table 1 Patient Demographics and Clinical Characteristics

Figure 2 Kaplan-Meier curve of microglobulin. (A) Kaplan-Meier curve of α1MG in the training cohort. (B) Kaplan-Meier curve of β2MG in the training cohort. (C) Kaplan-Meier curve of α1MG in the validation cohort. (D) Kaplan-Meier curve of β2MG in the validation cohort.

Abbreviations: α1MG, alpha1- macroglobulin; β2MG, beta2-microglobulin.
Figure 2 Kaplan-Meier curve of microglobulin. (A) Kaplan-Meier curve of α1MG in the training cohort. (B) Kaplan-Meier curve of β2MG in the training cohort. (C) Kaplan-Meier curve of α1MG in the validation cohort. (D) Kaplan-Meier curve of β2MG in the validation cohort.

Table 2 Univariate and Multivariable Analysis for Overall Survival of the Training Cohort

Figure 3 Nomograms for the prediction of 1-, 3- and 5-year OS. (A) The nomogram of the training cohort; (B) The nomogram of the validation cohort.

Abbreviations: MVI, microvascular invasion; CA199, carbohydrate antigen 199; β2MG, beta2-microglobulin.
Figure 3 Nomograms for the prediction of 1-, 3- and 5-year OS. (A) The nomogram of the training cohort; (B) The nomogram of the validation cohort.

Figure 4 Evaluation of the performance of the nomograms in the training cohort and validation cohort. (A) Calibration curves of the nomogram predicting 1-, 3- and 5-year OS in the training cohort. (B) Calibration curves of the nomogram predicting 1-, 3- and 5-year OS in the validation cohort. (C) ROC curves of the nomogram predicting 1-, 3- and 5-year OS in the training cohort. (D) ROC curves of the nomogram predicting 1-, 3- and 5-year OS in the validation cohort.

Abbreviations: OS, overall survival; ROC, receiver operating characteristic; AUC, area under the curve.
Figure 4 Evaluation of the performance of the nomograms in the training cohort and validation cohort. (A) Calibration curves of the nomogram predicting 1-, 3- and 5-year OS in the training cohort. (B) Calibration curves of the nomogram predicting 1-, 3- and 5-year OS in the validation cohort. (C) ROC curves of the nomogram predicting 1-, 3- and 5-year OS in the training cohort. (D) ROC curves of the nomogram predicting 1-, 3- and 5-year OS in the validation cohort.

Figure 5 Decision curve analysis for 5-year survival predictions. (A) The decision curve of the training cohort; (B) The decision curve of the validation cohort.

Figure 5 Decision curve analysis for 5-year survival predictions. (A) The decision curve of the training cohort; (B) The decision curve of the validation cohort.

Figure 6 Survival graph for all three groups based on the predictor from the nomogram model. (A) Kaplan-Meier curve in the training cohort. (B) Kaplan-Meier curve in the validation cohort.

Figure 6 Survival graph for all three groups based on the predictor from the nomogram model. (A) Kaplan-Meier curve in the training cohort. (B) Kaplan-Meier curve in the validation cohort.