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Review

Vitamin D and the immunomodulation of rotator cuff injury

, &
Pages 123-131 | Published online: 14 Jun 2016

Figures & data

Figure 1 Potential pathway demonstrating the effects of vitamin D on the RANK receptor and osteocyte differentiation.

Abbreviations: NF-κB, nuclear factor-κB; RANK, receptor activator of nuclear factor-κB; RANKL, receptor activator of nuclear factor-κB ligand; VDR, vitamin D receptor; c-Fms, colony-stimulating factor-1 receptor; TRAF6, TNF receptor associated factor-6.

Figure 1 Potential pathway demonstrating the effects of vitamin D on the RANK receptor and osteocyte differentiation.Abbreviations: NF-κB, nuclear factor-κB; RANK, receptor activator of nuclear factor-κB; RANKL, receptor activator of nuclear factor-κB ligand; VDR, vitamin D receptor; c-Fms, colony-stimulating factor-1 receptor; TRAF6, TNF receptor associated factor-6.

Figure 2 Potential effects of vitamin D on muscle cell differentiation and proliferation.

Abbreviation: BMP, bone morphogenetic protein.

Figure 2 Potential effects of vitamin D on muscle cell differentiation and proliferation.Abbreviation: BMP, bone morphogenetic protein.

Figure 3 Potential effects of vitamin D on tendon inflammation and healing.

Note: It has been shown that vitamin D decreases the production of MMPs, thus decreasing inflammation.

Abbreviations: JNK, c-Jun N-terminal kinase; MMP, matrix metalloproteinases; NF-κB, nuclear factor-κB; TNF-α, tumor necrosis factor-α; IκBα, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor; AP-1, activator protein 1.

Figure 3 Potential effects of vitamin D on tendon inflammation and healing.Note: It has been shown that vitamin D decreases the production of MMPs, thus decreasing inflammation.Abbreviations: JNK, c-Jun N-terminal kinase; MMP, matrix metalloproteinases; NF-κB, nuclear factor-κB; TNF-α, tumor necrosis factor-α; IκBα, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor; AP-1, activator protein 1.