Evaluation of chemokine CXCL10 in human gingival crevicular fluid, saliva, and serum as periodontitis biomarker

Figures & data

Table 1 Demographic characteristics of control and chronic periodontitis subjects

		Chronic periodontitis	Control
Mean age (years)		31.7	27.8
Range		18–59	18–48
gender	Female	20	20
	Male	11	5
Smoking history		6	0

Table 2 clinical periodontal parameters in chronic periodontitis and control subjects

	Chronic periodontitis	Control
PD (mean ± SD)	4.4±1.0	3.0±0.4a
Clinical attachment loss (mean ± SD)	3.1±1.4	0.36±0.4b
Percentage of PD ≥5 mm	18% (3–55)	1%
Percentage of CAL ≥3 mm	30% (3–100)	0.8%d
PI	2	1.9
GI	2.4	2.5

Notes:

a Mean PD in the periodontitis vs control groups: P=0.0001.

b Mean attachment level in the periodontitis vs control groups: P=0.001.

c Percentage of sites with PD ≥5 mm in the periodontitis vs control groups: P=0.001.

d Percentage of sites with CAL ≥3 in the periodontitis vs control groups: P=0.0001.

Abbreviations: CAL, clinical attachment level; GI, gingival index; PD, probing depth; PI, plaque index.

Figure 1 CXCL10 concentrations (pg/ml) in (A) saliva, (B) serum, and (C) GCF form the chronic periodontitis and control groups. The horizontal line represents the median value, and 75% and 25% quartiles are represented by the upper and lower edges of boxes, respectively. CXCL10 levels in saliva and serum in the chronic periodontitis vs control groups were different at statistically significant level (P<0.05).

Abbreviation: GCF, gingival crevicular fluid.

Figure 2 CXCL10 levels in saliva, serum, and GCF among smoker and nonsmoker subjects with chronic periodontitis.

Abbreviation: GCF, gingival crevicular fluid.

Figure 3 CXCL10 levels in saliva, serum, and GCF among subjects with mild periodontitis and moderate to severe periodontitis. *P≤0.05.

Abbreviation: GCF, gingival crevicular fluid.

Figure 4 CXCL10 levels in saliva, serum, and GCF among chronic periodontitis subjects of the two age groups. *P≤0.05.

Abbreviations: GCF, gingival crevicular fluid; yr, year.