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CASE SERIES

Lenalidomide Improves Cognitive Function and Reduces Immune Reconstitution Inflammatory Syndrome in HIV-1-Related Cryptococcal Meningitis

, , , , , , & show all
Pages 2891-2899 | Published online: 10 May 2022

Figures & data

Figure 1 Timeline for Case 1. (A) Axial cerebral magnetic resonance imaging (MRI) in T2-weighted sequences before lenalidomide treatment: the red arrow shows left frontal lobe hyperintensity. (B) Axial cerebral MRI: the red arrow shows the left frontal lobe lesion signal disappeared after lenalidomide treatment.

Figure 1 Timeline for Case 1. (A) Axial cerebral magnetic resonance imaging (MRI) in T2-weighted sequences before lenalidomide treatment: the red arrow shows left frontal lobe hyperintensity. (B) Axial cerebral MRI: the red arrow shows the left frontal lobe lesion signal disappeared after lenalidomide treatment.

Figure 2 Timeline for Case 2. (A) Axial cerebral magnetic resonance imaging (MRI) in T2-weighted sequences before lenalidomide treatment: the red arrow shows multiple regions of thickening and enhancement in the meninges. (B) Axial cerebral MRI: the red arrow shows the degree of meningeal enhancement was significantly reduced after lenalidomide treatment.

Figure 2 Timeline for Case 2. (A) Axial cerebral magnetic resonance imaging (MRI) in T2-weighted sequences before lenalidomide treatment: the red arrow shows multiple regions of thickening and enhancement in the meninges. (B) Axial cerebral MRI: the red arrow shows the degree of meningeal enhancement was significantly reduced after lenalidomide treatment.

Figure 3 Analysis of the correlation of Montreal Cognitive Assessment (MoCA) and International HIV Dementia Scale (IHDS) scores with cerebrospinal fluid (CSF) protein and CSF IgG in both patients through a linear regression analysis. Linear correlation between (A) MoCA and CSF protein, (B) MoCA and CSF IgG, (C) IHDS and CSF protein (D) IHDS and CSF IgG.

Figure 3 Analysis of the correlation of Montreal Cognitive Assessment (MoCA) and International HIV Dementia Scale (IHDS) scores with cerebrospinal fluid (CSF) protein and CSF IgG in both patients through a linear regression analysis. Linear correlation between (A) MoCA and CSF protein, (B) MoCA and CSF IgG, (C) IHDS and CSF protein (D) IHDS and CSF IgG.

Data Availability Statement

The original contributions generated for the study are included in the article. Further inquiries can be directed to the corresponding author.