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Journal of Inflammation Research Volume 15, 2022 - Issue
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ORIGINAL RESEARCH

Elevation of Preprocedural Systemic Immune Inflammation Level Increases the Risk of Contrast-Associated Acute Kidney Injury Following Coronary Angiography: A Multicenter Cohort Study

Wenguang Lai1 Department of Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, People’s Republic of China;2 School of Biology and Biological Engineering, South China University of Technology, Guangzhou, People’s Republic of ChinaView further author information
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Xiaoli Zhao3 Department of Cardiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, People’s Republic of ChinaView further author information
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Zhidong Huang1 Department of Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0002-5267-5769View further author information
ORCID Icon,
Yun Xie1 Department of Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, People’s Republic of China;2 School of Biology and Biological Engineering, South China University of Technology, Guangzhou, People’s Republic of ChinaView further author information
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Sijia Yu1 Department of Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, People’s Republic of China;4 The Second School of Clinical Medicine, Southern Medical University, Guangzhou, People’s Republic of ChinaView further author information
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Jiabin Tu5 Department of Cardiology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, 364000, People’s Republic of ChinaView further author information
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Dachuan Guo6 Department of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of ChinaView further author information
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Jiaming Xiu5 Department of Cardiology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, 364000, People’s Republic of ChinaView further author information
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Ziling Mai1 Department of Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, People’s Republic of China;2 School of Biology and Biological Engineering, South China University of Technology, Guangzhou, People’s Republic of ChinaView further author information
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Qiang Li1 Department of Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, People’s Republic of ChinaView further author information
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Haozhang Huang1 Department of Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, People’s Republic of China;4 The Second School of Clinical Medicine, Southern Medical University, Guangzhou, People’s Republic of ChinaView further author information
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Huanqiang Li1 Department of Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, People’s Republic of ChinaView further author information
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Jun-Yan Xu1 Department of Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, People’s Republic of China;7 Ministry of Education, Key Laboratory of Hainan Trauma and Disaster Rescue, College of Emergency and Trauma, Hainan Medical University, Haikou, 571199, People’s Republic of ChinaView further author information
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Hongyu Lu1 Department of Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, People’s Republic of ChinaView further author information
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Guanzhong Chen1 Department of Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, People’s Republic of ChinaView further author information
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Shiqun Chen1 Department of Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, People’s Republic of ChinaView further author information
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Jin Liu1 Department of Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, People’s Republic of ChinaView further author information
&
Yong Liu1 Department of Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, People’s Republic of ChinaCorrespondence[email protected] [email protected]
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Pages 2959-2969 | Published online: 13 May 2022

Figures & data

Table 1 Baseline Characteristics According to Preprocedural SII Level Categories

Figure 1 The incidence of CA-AKI in the four groups.

Figure 1 The incidence of CA-AKI in the four groups.

Figure 2 The incidence of one-year mortality in the four groups.

Figure 2 The incidence of one-year mortality in the four groups.

Figure 3 Kaplan–Meier curve in terms of all-cause mortality according to the preprocedural SII quartiles.

Figure 3 Kaplan–Meier curve in terms of all-cause mortality according to the preprocedural SII quartiles.

Table 2 Univariable and Multivariable Logistic Regression Analysis of the Association Between Preprocedural SII Level and CA-AKI Following CAG

Figure 4 Multivariable logistic regression analysis for association between preprocedural SII and CA-AKI in different models. Model 1 was unadjusted; model 2 was only adjusted for age and gender; model 3 was adjusted for ACEI_ARB, Age, AMI, Anemia, CAD, CMV, CHF, DM, eGFR, gender, HT, HDL-C, IABP, LDL-C, PCI, Statins.

Abbreviations: OR, odds ratios; CI, confidence interval.
Figure 4 Multivariable logistic regression analysis for association between preprocedural SII and CA-AKI in different models. Model 1 was unadjusted; model 2 was only adjusted for age and gender; model 3 was adjusted for ACEI_ARB, Age, AMI, Anemia, CAD, CMV, CHF, DM, eGFR, gender, HT, HDL-C, IABP, LDL-C, PCI, Statins.

Figure 5 Restricted spline curve for the CA-AKI adjusted odds ratio.

Figure 5 Restricted spline curve for the CA-AKI adjusted odds ratio.

Figure 6 Receiver operator characteristics curves of Mehran risk score, Mehran+SII, Mehran+NLR and Mehran+PLR model.

Figure 6 Receiver operator characteristics curves of Mehran risk score, Mehran+SII, Mehran+NLR and Mehran+PLR model.

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