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ORIGINAL RESEARCH

An Integrated Analysis of Inflammatory Endotypes and Clinical Characteristics in Chronic Rhinosinusitis with Nasal Polyps

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Pages 5557-5565 | Received 03 Jun 2022, Accepted 15 Sep 2022, Published online: 24 Sep 2022

Figures & data

Table 1 Baseline Characteristics of Control Subjects and CRSwNP Patients

Figure 1 Patterns of inflammatory endotypes in CRSwNP. (A-D) The proportions of specific (B-D), single (A), mixed (A) and untypeable (A) endotypes. (E-G) The mRNA expression levels of IFN-γ (E), CLC (F) and IL-17A (G). (H-J) The correlations of mRNA expression levels for IFN-γ (H, I), CLC (I, J) and IL-17A (H, J). ****P < 0.0001.

Figure 1 Patterns of inflammatory endotypes in CRSwNP. (A-D) The proportions of specific (B-D), single (A), mixed (A) and untypeable (A) endotypes. (E-G) The mRNA expression levels of IFN-γ (E), CLC (F) and IL-17A (G). (H-J) The correlations of mRNA expression levels for IFN-γ (H, I), CLC (I, J) and IL-17A (H, J). ****P < 0.0001.

Figure 2 Clinical characteristics in specific inflammatory endotypes. (A-H) The scores of nasal congestion (A), purulent rhinorrhea (B), smell loss (C), headache/facial pain (D), sneezing (E), nasal itching (F), eye itching (G) and total symptom scores (H). (I-L) The scores for rhinology (I), ear/facial (J), sleep dysfunction (K) and SNOT-22 total scores (L). *P < 0.05, **P < 0.01 and ***P < 0.001.

Figure 2 Clinical characteristics in specific inflammatory endotypes. (A-H) The scores of nasal congestion (A), purulent rhinorrhea (B), smell loss (C), headache/facial pain (D), sneezing (E), nasal itching (F), eye itching (G) and total symptom scores (H). (I-L) The scores for rhinology (I), ear/facial (J), sleep dysfunction (K) and SNOT-22 total scores (L). *P < 0.05, **P < 0.01 and ***P < 0.001.

Figure 3 Prevalence of comorbid atopy (A), asthma (B) and recurrence (C) in specific inflammatory endotypes. *P < 0.05 and **P < 0.01.

Figure 3 Prevalence of comorbid atopy (A), asthma (B) and recurrence (C) in specific inflammatory endotypes. *P < 0.05 and **P < 0.01.

Figure 4 Odds ratio (OR) and 95% confidence interval (CI) of headache/facial pain (A), smell loss (B), purulent rhinorrhea (C) in specific inflammatory endotypes. *P < 0.05 and **P < 0.01.

Figure 4 Odds ratio (OR) and 95% confidence interval (CI) of headache/facial pain (A), smell loss (B), purulent rhinorrhea (C) in specific inflammatory endotypes. *P < 0.05 and **P < 0.01.

Figure 5 Clinical characteristics in single, mixed and untypeable inflammatory endotypes. (A-F) The scores of nasal congestion (A), purulent rhinorrhea (B), smell loss (C), sneezing (D), eye itching (E) and total symptom scores (F). (G-I) The scores for rhinology (G), sleep dysfunction (H) and SNOT-22 total scores (I). *P < 0.05, **P < 0.01 and ***P < 0.001.

Figure 5 Clinical characteristics in single, mixed and untypeable inflammatory endotypes. (A-F) The scores of nasal congestion (A), purulent rhinorrhea (B), smell loss (C), sneezing (D), eye itching (E) and total symptom scores (F). (G-I) The scores for rhinology (G), sleep dysfunction (H) and SNOT-22 total scores (I). *P < 0.05, **P < 0.01 and ***P < 0.001.