The Relationship Between Plasma Selenium, Antioxidant Status, Inflammatory Responses and Ischemic Cardiomyopathy: A Case-Control Study Based on Matched Propensity Scores

Figures & data

Table 1 The Baseline Characteristics of the Subjects

Characteristics	Before Propensity Matching
	ICM(n=43)	Control Group (n=76)	P-value
Gender=male, n (%)	27 (62.8)	35 (46.1)	0.118
Age (median [IQR])	66.00 [60.00, 74.00]	47.00 [36.00, 60.75]	<0.001*
N (median [IQR])	63.80 [60.20, 70.45]	59.70 [54.15, 65.75]	0.006*
Monocyte (median [IQR])	7.00 [5.90, 8.55]	5.70 [4.95, 6.90]	<0.001*
RDW (median [IQR])	13.50 [13.05, 14.30]	12.70 [12.40, 13.17]	<0.001*
Hb (median [IQR])	124.00 [113.00, 140.00]	144.00 [137.00, 157.00]	<0.001*
PLT (mean (SD))	168.67 (55.19)	217.03 (56.51)	<0.001*
MPV (median [IQR])	11.20 [10.15, 12.30]	10.50 [10.00, 11.20]	0.02*
PDW (mean (SD))	14.72 (4.68)	17.60 (15.59)	0.241
L (mean (SD))	23.36 (8.72)	30.85 (7.97)	<0.001*
WBC (median [IQR])	5.84 [4.66, 7.04]	5.81 [4.94, 6.63]	0.771
ALT (median [IQR])	16.00 [11.00, 24.50]	14.00 [11.00, 22.75]	0.295
TG (median [IQR])	1.20 [0.80, 1.57]	1.15 [0.88, 1.88]	0.489
Height (mean (SD))	160.39 (9.41)	160.66 (7.88)	0.881
Weight (median [IQR])	62.00 [53.75, 67.00]	58.00 [51.00, 66.00]	0.385
Cr (median [IQR])	75.75 [58.30, 97.97]	56.40 [49.70, 68.20]	<0.001*
GLU (median [IQR])	5.39 [4.76, 6.57]	5.17 [4.78, 5.58]	0.099
UA (median [IQR])	381.59 [313.99, 485.77]	319.02 [262.70, 385.16]	0.004*
SBP (median [IQR])	120.00 [119.00, 130.00]	130.00 [114.00, 141.50]	0.126
Characteristics	After Propensity Matching
	ICM(n=43)	Control Group (n=46)		P-value
Gender=male, n (%)	27 (62.8)	22 (47.8)		0.228
Age (median [IQR])	66.00 [60.00, 74.00]	57.50 [49.00, 67.75]		0.001*
N (median [IQR])	63.80 [60.20, 70.45]	62.50 [57.33, 68.38]		0.19
Monocyte (mean (SD))	9.41 (14.42)	6.19 (1.62)		0.137
RDW (mean (SD))	14.03 (1.96)	12.90 (0.96)		0.001*
Hb (mean (SD))	124.76 (28.80)	142.74 (16.44)		<0.001*
PLT (mean (SD))	168.67 (55.19)	206.83 (47.55)		0.001*
MPV (median [IQR])	11.20 [10.15, 12.30]	10.60 [10.20, 11.30]		0.115
PDW (mean (SD))	14.72 (4.68)	15.58 (3.33)		0.325
L (median [IQR])	25.20 [16.80, 30.05]	28.30 [23.10, 32.85]		0.007
WBC (mean (SD))	5.98 (1.87)	5.94 (1.46)		0.899
ALT (mean (SD))	28.12 (52.73)	17.67 (12.69)		0.196
TG (mean (SD))	1.27 (0.61)	1.53 (1.40)		0.273
Height (mean (SD))	160.39 (9.41)	159.61 (7.85)		0.704
Weight (median [IQR])	62.00 [53.75, 67.00]	57.00 [52.00, 65.00]		0.23
Cr (median [IQR])	75.75 [58.30, 97.97]	57.40 [50.92, 66.28]		<0.001*
GLU (mean (SD))	6.27 (2.41)	5.44 (0.98)		0.035
UA (mean (SD))	405.06 (126.83)	337.65 (96.40)		0.006
SBP (mean (SD))	124.40 (13.69)	136.41 (19.94)		0.001*

Notes: *p<0.05.

Abbreviations: N, neutrophil count; RDW, red cell distribution width; Hb, haemoglobin concentration; PLT, platelet count; MPV, mean platelet volume; PDW, Platelet distribution width; L, lymphocyte count; WBC, white blood cell count; ALT, glutathione transaminase concentration; TG, total triglycerides; Cr, creatinine; GLU, fasting blood glucose; UA, uric acid; SBP, systolic blood pressure.

Table 2 Plasma Selenium Levels and Biomarker Index Levels Between Groups

Characteristics	Before Propensity Matching
	ICM(n=43)		Control Group (n=76)	P-value
Plasma selenium (ug/L)	68.83874		88.1041	0.05388
MDA (pg/mL)	61.63078		36.96151	<0.001
SOD (pg/mL)	6.985458		21.625456	<0.001
IL-6 (pg/mL)	49.41484		37.66494	<0.001
N/L	3.696574		2.159665	<0.001
TNF-a (pg/mL)	79.09773		45.03701	<0.001
Characteristics	After propensity Matching
	ICM(n=43)	Control Group (n=46)		P-value
Plasma selenium (ug/L)	68.83874	104.39775		0.02032
MDA (pg/mL)	61.63078	39.0609		<0.001
SOD (pg/mL)	6.985458	18.473624		<0.001
IL-6 (pg/mL)	49.41484	38.46923		<0.001
N/L	3.696574	2.383658		0.006951
TNF-a (pg/mL)	79.09773	46.15634		<0.001

Abbreviations: SOD, superoxide dismutase; MDA, malondialdehyde; IL-6, interleukin-6; TNF-a, tumour necrosis factor-a;N/L, ratio of neutrophils to lymphocytes.

Figure 1 The age and gender of the two groups tended to be balanced after matching, the matching effect was satisfied.

Table 3 Pearson Correlation Coefficient Between Plasma Selenium Level and Other Variables

Variable	Plasma Selenium	p
Serum SOD	−0.00405451	0.9699
Serum MDA	−0.2406963	0.02308*
Serum IL-6	−0.3347915	0.001342*
N/L	−0.1538448	0.15
Serum TNF-a	−0.2336118	0.02757*

Notes: *p<0.05.

Abbreviations: SOD, superoxide dismutase; MDA, malondialdehyde; IL-6, interleukin-6; TNF-a, tumour necrosis factor-a; N/L, ratio of neutrophils to lymphocytes.