Construction of a Nomogram for Identifying Refractory Mycoplasma pneumoniae Pneumonia Among Macrolide-Unresponsive Mycoplasma pneumoniae Pneumonia in Children

Figures & data

Table 1 Patient Characteristics

Characteristic	NRMPP (n=106)	RMPP (n=56)	P value
Age (year), mean±SD	6.44±3.64	8.93±4.19	<0.001
Male/female	47/59	24/32	0.989
Weight (kg), mean±SD	24.65±10.57	26.66±9.90	0.242
Leukocyte count (×10^9/L), mean±SD	17.38±4.63	22.29±6.30	<0.001
Neutrophil proportion (%), mean±SD	81.07±9.38	86.61±3.72	<0.001
Platelets count (×10^9), mean±SD	202.46±54.76	219.09±51.70	0.063
C-reactive protein (mg/L), mean±SD	17.32±6.22	20.43±5.75	0.002
Albumin (g/L), n (%)			0.260
≥30	51 (48.1)	21 (37.5)
<30	55 (51.9)	35 (62.5)
Erythrocyte sedimentation rate (mm/h), mean±SD	36.40±12.83	41.18±16.57	0.044
Serum procalcitonin (ng/mL), mean±SD	1.04±0.38	1.49±0.51	<0.001
Lactate dehydrogenase (IU/L), mean±SD	477.25±264.87	761.96±260.05	<0.001
Coinfection with other respiratory pathogens, n (%)	6 (5.7)	9 (16.1)	0.059

Abbreviations: NRMPP, non-refractory Mycoplasma pneumoniae pneumonia; RMPP, refractory Mycoplasma pneumoniae pneumonia; SD, standard deviation.

Table 2 Severity of MUMPP Continuing to Receive Macrolide After the Confirmation of MUMPP

Characteristic	NRMPP (n=106)	RMPP (n=56)	P value
Duration of corticosteroid treatment (days), mean±SD	2.61±1.10	3.27±1.36	0.001
Duration of hospital stay (days), mean±SD	6.89±1.93	7.64±1.69	0.015
Extrapulmonary symptoms, n (%)			0.045
Yes	15 (14.2)	16 (28.6)
No	91 (85.8)	40 (71.4)
Parapneumonic effusion, n (%)			<0.001
Yes	28 (26.4)	37 (66.1)
No	78 (73.6)	19 (33.9)

Abbreviations: MUMPP, macrolide-unresponsive Mycoplasma pneumoniae pneumonia; NRMPP, non-refractory Mycoplasma pneumoniae pneumonia; RMPP, refractory Mycoplasma pneumoniae pneumonia; SD, standard deviation.

Table 3 Variables Associated with RMPP Among MUMPP Children Continuing to Receive Macrolide After the Confirmation of MUMPP in Multivariable Logistic Regression Analysis

Variable	OR (95% CI)	P value
Age	1.201(1.056–1.383)	0.007
Leukocyte count	1.223(1.103–1.382)	0.000
Neutrophil proportion	1.198(1.075–1.372)	0.004
C-reactive protein	1.037(0.956–1.130)	0.384
Erythrocyte sedimentation rate	1.013(0.979–1.050)	0.453
Serum procalcitonin	6.439(2.202–22.203)	0.001
Lactate dehydrogenase	1.003(1.002–1.006)	0.001

Abbreviations: MUMPP, macrolide-unresponsive Mycoplasma pneumoniae pneumonia; RMPP, refractory Mycoplasma pneumoniae pneumonia; OR, odds ratio; CI, confidence interval.

Figure 1 Nomogram for predicting RMPP in children continuing to receive macrolide after the confirmation of MUMPP.

Abbreviations: RMPP, refractory Mycoplasma pneumoniae pneumonia; MUMPP, macrolide-unresponsiveMycoplasma pneumoniae pneumonia.

Figure 2 The ROC analysis for the predictive model.

Abbreviation: ROC, receiver operating characteristic.

Figure 3 The calibration curve indicated good consistency between the actual diagnosed RMPP and the predicted probability.

Abbreviation: RMPP, refractory Mycoplasma pneumoniae pneumonia.