Ferroptosis: Reviewing CRC with the Third Eye

Figures & data

Figure 1 Schematic diagram of the mechanism of ferroptosis. Ferroptosis is a form of regulated cell death driven by iron-dependent lipid peroxidation. Ferroptosis is the result of imbalance in redox systems. The accumulation of ROS mainly mediated by iron overload is the key step which would lead to lipid peroxidation and destroy the cell membrane. GPX4 mediated enzymatic antioxidant process is a crucial defense mechanism against lipid peroxidation. The FSP1/CoQ10 axis also plays a role in negatively regulating ferroptosis.

Table 1 Regulators of Ferroptosis and Brief Mechanisms in CRC

Category	Molecular/Drug	Target Molecular/Regulatory Pathway	Function	Reference
Gene	SRSF9	GPX4	–	[30]
	TP53	DPP4	–	[42]
lncRNA	LNC01616	miR-423-5p/SCD1/Wnt/β-catenin	–	[47]
miRNA	miR-15a-3p	GPX4	+	[50]
	miR-539	SAPK/JAK	+	[51]
	miR-545	TF	–	[52]
circRNA	Circ_0007124	miR-874-3p/GDPD5	+	[56]
	CircABCB10	MiR-326/CCL5	–	[57]
Other	HIF-2α	Iron	+	[68]
	OTUD1	IREB2	+	[69]
	LCN2	Iron	–	[71]
	KIF20A	NUAK1/PP1β/GPX4	–	[73]
	VitC	ROS	+	[76]
Drug	Erastin	SLC7A11	+	[23]
	RSL3	GPX4	+	[24]
	Cetuximab	Nrf2/HO-1	+	[65]
	Tagitinin C	Nrf2/HO-1	+	[66]
	B.etnensis Raf.	HO-1	+	[67]
	Apatinib	ELOVL6/ACSL4, GPX4, FTH1	+	[78]
	DCA	Iron	+	[79]
	IMCA	AMOK/Mtor/p70S6k/SLC7A11	+	[80]
	Bromelain	ACSL4	+	[81]
	PunA		+	[82]
	talaA	SLC7A11, ROS	+	[83]
	Auriculasin	ROS	+	[84]
	NC06	Asah2/P53/HMOX1	+	[88]
	BEBT-908	PI3K/HDAC	+	[89]
	DHA	ROS	+	[90]

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