LncRNA THRIL Functions as a Marker for Carotid Artery Stenosis and Affects the Biological Function of Human Aortic Endothelial Cell

Figures & data

Figure 1 A flowchart of included patients.

Table 1 Clinical Statistical Information of Recruited Individuals

Parameter	Controls (n = 81)	CAS (n = 88)	P value
Age (years)	62.68 ± 10.27	63.31 ± 9.46	0.680
Gender (male, %)	44, 54.32	44, 50.00	0.574
Smoking (n, %)	24, 29.63	33, 37.50	0.280
Diabetes mellitus (n, %)	29, 35.81	31, 35.23	0.938
Hypertension (n, %)	37, 45.68	56, 63.64	0.019
BMI (kg/m^2)	23.10 ± 2.76	23.36 ± 2.61	0.531
LDL-C (mmol/l)	2.88 ± 0.64	2.81 ±0.62	0.443
HDL-C (mmol/l)	1.29 ± 0.24	1.32 ± 0.24	0.411
TC (mmol/l)	4.91 ± 0.91	5.14 ± 0.64	0.055
TG (mmol/l)	1.46 ± 0.37	1.48 ± 0.34	0.731
Degree of CAS (%)	/	66.19 ± 8.74	/

Abbreviations: CAS, carotid stenosis; BMI, body mass index; LDL, low density lipoprotein; HDL, high-density lipoprotein; TC, total cholesterol; TG, triglycerides.

Figure 2 An enforced expression of THRIL in CAS patients. ***P < 0.001.

Figure 3 The AUC of THRIL for predicting poor prognosis in patients with asymptomatic CAS was 0.904.

Figure 4 The K-M curve estimated the prognostic value of THRIL.

Table 2 Cox Regression Multivariate Analysis for Overall Survival in CAS

Parameter	Hazard Ratio	95.0% CI		P value
		Lower	Upper
THRIL expression	0.222	0.069	0.713	0.011
Age (years)	1.068	0.343	3.330	0.910
Gender (male, %)	1.106	0.409	2.989	0.843
Smoking (n, %)	1.436	0.510	4.041	0.493
Diabetes mellitus (n, %)	0.997	0.360	2.761	0.996
Hypertension (n, %)	0.868	0.316	2.388	0.784
BMI (kg/m^2)	1.125	0.416	3.047	0.816
LDL-C (mmol/l)	1.411	0.521	3.824	0.499
HDL-C (mmol/l)	1.511	0.546	4.183	0.427
TC (mmol/l)	0.764	0.261	2.238	0.624
TG (mmol/l)	1.068	0.350	3.255	0.909
Degree of CAS (%)	0.293	0.100	0.855	0.025

Abbreviations: CAS, carotid stenosis; BMI, body mass index; LDL, low density lipoprotein; HDL, high-density lipoprotein; TC, total cholesterol; TG, triglycerides.

Figure 5 (A) The si-THRIL reversed the up-regulation of THRIL in the ox-LDL group. (B-D) THRIL regulated the cell proliferation, apoptosis, and inflammation steered by ox-LDL. ***P < 0.001, in comparison with control cells; ##P < 0.01, ###P < 0.001, in comparison with ox-LDL group.