https://orcid.org/0000-0003-3817-6696
Figures & data
Figure 1 The molecular mechanisms of pyroptosis and ferroptosis.
Abbreviations: ACSL4, acyl-CoA synthetase long-chain family member 4; LPCAT3, lysophosphatidylcholine acyltransferase 3; DMT1, divalent metal transporter 1; TFR1, transferrin receptor 1; Glu, glutamate; SLC3A2, solute carrier family 3 member 2; SLC7A11, solute carrier family 7 member 11; GSH, glutathione; GPX4, glutathione peroxidase 4; BSO, L-buthionine-(S,R)-sulfoximine; Se, selenium; RSL3, RAS-selective lethal 3; FIN, ferroptosis inducer; ML, molecular libraries; BH4, tetrahydrobiopterin; GCH1, GTP cyclohydrolase-1; FSP1, ferroptosis suppressor protein 1; RTAs, radical-trapping antioxidants; ASC, apoptosis-associated speck-like protein containing a caspase recruitment domain; GSDMD, gasdermin-D; IL-1β/18, interleukin-1β/18.
Figure 2 The molecular mechanism of necroptosis.
Abbreviations: TNF, tumor necrosis factor; TNFR1, TNF receptor 1; TRAF2, TNF receptor-associated factor 2; TRAF5, TNF receptor-associated factor 5; TRADD, TNFR1-associated death domain protein; cIAP, cellular inhibitor of apoptosis protein; RIP1, receptor interacting protein-1; RIP3, receptor interacting protein-3; Lys63-Ub, lysine-63 ubiquitinated protein; CYLD, cylindromatosis; cFLIP, cellular FLICE-like inhibitory protein; FADD, Fas-associated protein with death domain; DISC, death-inducing signaling complex; NF-κB, nuclear factor kappa-B; MAPKs, mitogen-activated protein kinases.
