Expression and Significance of KIM-1, NGAL, and HO-1 in Patients with Acute Kidney Injury After Cardiac Valve Replacement

Figures & data

Table 1 Comparison of General Clinical Data of Patients Between the Two Groups () [n (%)]

Category	AKI Group (n=22)	Non-AKI Group (n=58)	T value or x^2 value	P value
Age (years old)	60.46±6.16	58.48±5.63	0.654	0.448
Male (n, %)	14 (63.63)	38 (65.51)	0.025	0.875
Weight (kg)	66.47±10.38	65.49±9.06	1.547	0.316
Medical history
Hypertension (n, %)	6	8		0.192*
Type II diabetes (n, %)	3	4		0.386*
Coronary heart disease (n, %)	4	3		0.086*
Surgical method
Mitral valve replacement	12 (37.5)	24 (52.5)	1.117	0.292
Aortic valve replacement	6 (35.0)	22 (37.5)	0.796	0.372
Double valve replacement	4 (27.5)	12 (10.0)		0.063*

Note: *Fisher’s exact probability method.

Table 2 Comparison of KIM-1, NGAL, and HO-1 at Different Point in Times of the AKI Group ()

Indicator	n	Pre-Operation	12 Hours Post-Operation	24 Hours Post-Operation	48 Hours Post-Operation	P
KIM-1 (ng/mL)	22	52.26±30.86	69.11±56.26*	102.38±56.24*	86.64±53.19*	P < 0.05
NGAL (ng/mL)	22	36.88±10.48	153.04±40.45*	289.49±109.70*	158.72±25.36*	P < 0.05
HO-1 (µmol/l)	22	27.07±10.09	143.02±20.68*	175.69±26.70*	115.57±18.87*	P < 0.05

Notes: Intra-group comparison with preoperative, *P < 0.05.

Table 3 Comparison of KIM-1, NGAL, and HO-1 at Different Point in Times of the Non-AKI Group ()

Indicator	n	Pre-Operation	12 Hours Post-Operation	24 Hours Post-Operation	48 Hours Post-Operation	P
KIM-1 (ng/mL)	58	50.83±20.38	58.78±13.29*	93.47±34.52*	58.97±10.30*	P >0.05
NGAL (ng/mL)	58	30.03±12.11	84.06±9.29*	86.74±9.69*	78.87±8.54*	P >0.05
HO-1 (µmol/l)	58	26.30±9.08	29.96±10.80	30.12±7.89*	38.87±6.76*	P >0.05

Notes: intra-group comparison with preoperative, * P >0.05.

Table 4 Comparison of KIM-1, NGAL, and HO-1 Between the Two Groups ()

Indicator	Group	n	Pre-Operation	12 Hours Post-Operation	24 Hours Post-Operation	48 Hours Post-Operation	P
KIM-1 (ng/mL)	AKI	22	52.26±30.86	69.11±56.26#	102.38±56.24#	86.64±53.19#	P < 0.05
	Non-AKI	58	50.83±20.38	58.78±13.29	93.47±34.52	58.97±10.30
NGAL (ng/mL)	AKI	22	36.88±10.48	153.04±40.45#	289.49±109.70#	158.72±25.36#	P < 0.05
	Non-AKI	58	30.03±12.11	84.06±9.29	86.74±9.69	78.87±8.54
HO-1 (µmol/l)	AKI	22	27.07±10.09	143.02±20.68#	175.69±26.70#	115.57±18.87#	P < 0.05
	Non-AKI	58	26.30±9.08	29.96±10.80	30.12±7.89	38.87±6.76

Notes: AKI group comparison with non-AKI group, ^#P < 0.05.

Table 5 Comparison of SCr and BUN at Different Point in Times of the AKI Group () (n=22)

Indicator	Group	Pre-Operation	12 Hours Post-Operation	24 Hours Post-Operation	48 Hours Post-Operation
SCr (µmol/l)	AKI	68.75±7.69	82.39±9.25*	94.49±9.56*	118.68±13.18*
BUN (mmol/l)	AKI	5.34±0.42	6.74±1.53*	14.13±2.42*	10.74±0.95*

Notes: Intra-group comparison with preoperative, *P < 0.05.

Table 6 Comparison of SCr and BUN at Different Point in Times of the Non-AKI Group () (n=58)

Indicator	Group	Pre-Operation	12 Hours Post-Operation	24 Hours Post-Operation	48 Hours Post-Operation
SCr (µmol/l)	Non-AKI	67.30±6.91	68.54±8.03*	70.06±8.34*	73.06±8.26*
BUN (mmol/l)	Non-AKI	5.06±0.41	5.80±0.49*	5.67±0.48*	6.07±0.39*

Notes: Intra-group comparison with preoperative, *P >0.05.

Table 7 Comparison of SCr and BUN in the Two Groups During the Perioperative Period ()

Indicator	Group	n	Pre-Operation	12 Hours Post-Operation	24 Hours Post-Operation	48 Hours Post-Operation
SCr	AKI	22	68.75±7.69	82.39±9.25#	94.49±9.56#	118.68±13.18#
(µmol/l)	Non-AKI	58	67.30±6.91	68.54±8.03	70.06±8.34	73.06±8.26
BUN	AKI	22	5.34±0.42	6.74±1.53#	14.13±2.42#	10.74±0.95#
(mmol/l)	Non-AKI	58	5.06±0.41	5.80±0.49	5.67±0.48	6.07±0.39

Notes: AKI group comparison with non-AKI group, ^#P < 0.05.