https://orcid.org/0009-0007-8612-6120
Figures & data
Figure 1 In neurons, microglia, astrocytes and macrophages, miRNAs regulate inflammatory factors by acting on various target genes after spinal cord injury, thereby relieving or worsening neuropathic pain.
Abbreviations: PAX2, pair box gene2; MEK, mitogen-activated protein kinase kinase; ERK, extracellular signal regulated kinases; NF-κB, nuclear factor kappa-B; p-38, p38 MAPK; MAPK, mitogen-activated protein kinases; GAP43, growth-associated protein 43; Ngn1, neurogenin-1; C-myc, V-Myc avian myelocytomatosis viral oncogene homolog; BDNF, brain-derived neurotrophic factor; PPAR-γ, peroxisome proliferator-activated receptor γ; IκKβ, inhibitor of kappa B kinase β; NeuroD1, neuronal differentiation 1; NeuroD4, neuronal differentiation 4; Mst1, macrophage stimulating 1; HMGB1, high mobility group protein 1; TLR4, toll-like receptor 4; p-IκBα, phosphorylated NF-kappa-B inhibitor alpha; SOCS1, suppressor of cytokine signaling1.
Figure 2 Interactions between lncRNAs/CircRNAs and miRNAs in neurons, microglia, astrocytes and macrophages alter the expression of inflammatory factors that affect neuropathic pain after spinal cord injury.
Abbreviations: HIF-α, hypoxia-inducible factor-1α; PI3K, phosphoinositide 3-Kinase; AKT, protein kinase B; LRRTM1, leucine-rich repeat transmembrane neuronal protein 1; NLRP3, nod-like receptor thermal protein domain associated protein 3; CDK6, cyclin-dependent kinase 6; KLF4, kruppel-like factor 4; mEKK1, MAPK/ERK kinase kinase 1; p-38, p38 MAPK; MAPK, mitogen activated protein kinases; p-JNK, jun n terminal kinase phosphorylated; NeuroD4, neuronal differentiation 4; CD84 (SLAMF5), signaling lymphocytic Activation Molecule Family 5; AQP4, aquaporin-4.
