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REVIEW

Potential Mechanism of Fatigue Induction and Its Management by JAK Inhibitors in Inflammatory Rheumatic Diseases

ORCID Icon, ORCID Icon, , ORCID Icon & ORCID Icon
Pages 3949-3965 | Received 28 Mar 2023, Accepted 27 Jul 2023, Published online: 08 Sep 2023

Figures & data

Figure 1 The possible metabolic pathways of inflammation that may stimulate the onset of fatigue. All the pathways shown on the picture are described in the text. The possible places of intervention by JAKi treatment are shown on the picture and described in an article as well.

Abbreviations: ERN1, endoplasmic reticulum to nucleus signalling 1; IDO-1, indoleamine 2.3-dioxygenase; JAKi, JAK inhibitors; JAKs, Janus Kinases; MASP-1, mannose-associated serine protease 1; PRDM-1 (BLIMP-1), B lymphocyte-induced maturation protein-1; ROS, reactive oxygen species; RTP4, receptor transporter protein 4; TDO, tryptophan 2.3-dioxygenase.
Figure 1 The possible metabolic pathways of inflammation that may stimulate the onset of fatigue. All the pathways shown on the picture are described in the text. The possible places of intervention by JAKi treatment are shown on the picture and described in an article as well.