125
Views
0
CrossRef citations to date
0
Altmetric
REVIEW

Molecular Mechanisms of Ferroptosis and Their Involvement in Acute Kidney Injury

ORCID Icon, , &
Pages 4941-4951 | Received 26 Jun 2023, Accepted 10 Oct 2023, Published online: 01 Nov 2023

Figures & data

Figure 1 Regulatory mechanisms of ferroptosis. The figure shows two main types of ferroptosis regulation: The first category involves metabolic pathways, such as the aberrant iron, lipid, and amino acid metabolic pathways in ferroptosis; the second category involves signaling pathways, such as he p53, nuclear factor erythroid 2-related factor, ferroptosis suppressor protein 1, guanosine triphosphate cyclohydrolase 1 and nuclear receptor coactivator 4 pathways.

Figure 1 Regulatory mechanisms of ferroptosis. The figure shows two main types of ferroptosis regulation: The first category involves metabolic pathways, such as the aberrant iron, lipid, and amino acid metabolic pathways in ferroptosis; the second category involves signaling pathways, such as he p53, nuclear factor erythroid 2-related factor, ferroptosis suppressor protein 1, guanosine triphosphate cyclohydrolase 1 and nuclear receptor coactivator 4 pathways.

Figure 2 Regulatory mechanism of ferroptosis in AKI. This figure displays the crosstalk between IRI, RM, FA, Cisplatin and ferroptosis in AKI. Created with BioRender.com.

Figure 2 Regulatory mechanism of ferroptosis in AKI. This figure displays the crosstalk between IRI, RM, FA, Cisplatin and ferroptosis in AKI. Created with BioRender.com.