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ORIGINAL RESEARCH

Development and External Validation of a Nomogram for Predicting the Effect of RTX on the Treatment of Membranous Nephropathy

, , , , &
Pages 4399-4411 | Received 29 Jun 2023, Accepted 03 Oct 2023, Published online: 06 Oct 2023

Figures & data

Figure 1 The flowchart of this study.

Figure 1 The flowchart of this study.

Table 1 Baseline Characteristics of PLA2R Antibody-Associated MN Patients Treated with Rituximab

Table 2 Number of PLA2R Antibody-Associated MN Patients Achieving Immunological Remission Within 6 Months After Treated with Rituximab for One Cycle

Table 3 Comparison of Clinical Characteristics Between Responders and Nonresponders

Table 4 Predictive Factors Related to Immunological Remission in 108 PLA2R Antibody-Associated MN Patients Receiving One Cycle of Rituximab Within 6 Months: Univariate Analysis

Table 5 Predictive Factors Related to Immunological Remission in 108 PLA2R Antibody-Associated MN Patients Receiving One Cycle of Rituximab Within 6 Months: Multivariate Logistic Regression Analysis (Forward, LR, α= 0.05)

Figure 2 ROC curves for PLA2R antibody, hemoglobin, and gender to predict immunological remission in patients with membranous nephropathy.

Abbreviations: ROC, receiver operating characteristic; PLA2R, phospholipase A2 receptor.
Figure 2 ROC curves for PLA2R antibody, hemoglobin, and gender to predict immunological remission in patients with membranous nephropathy.

Figure 3 Kaplan–Meier curve for the the cumulative immunological remission rate of patients stratified by PLA2R antibody (A), gender (B) and hemoglobin (C) is shown for immunological remission.

Abbreviation: PLA2R, phospholipase A2 receptor.
Figure 3 Kaplan–Meier curve for the the cumulative immunological remission rate of patients stratified by PLA2R antibody (A), gender (B) and hemoglobin (C) is shown for immunological remission.

Figure 4 A novel nomogram predicting for the probability of immunological remission. To use the nomogram, the specific point for each variable of the patient lies on each variable axis. Draw a vertical line upward to determine the point at which each variable accepts. The sum of these points is located on the Total Points axis, and draw a vertical line down to horizontal axis to determine the probability of immunological remission.

Figure 4 A novel nomogram predicting for the probability of immunological remission. To use the nomogram, the specific point for each variable of the patient lies on each variable axis. Draw a vertical line upward to determine the point at which each variable accepts. The sum of these points is located on the Total Points axis, and draw a vertical line down to horizontal axis to determine the probability of immunological remission.

Figure 5 The ROC curve and the AUC value to evaluate the discrimination ability of the nomogram in the training and validation datasets.

Abbreviations: ROC, receiver operating characteristic; AUC, area under the receiver operating characteristic curve.
Figure 5 The ROC curve and the AUC value to evaluate the discrimination ability of the nomogram in the training and validation datasets.

Figure 6 Calibration curves of the nomogram in the training and validation datasets. The y-axis indicates the observed cumulative incidence for immunological remission, and the x-axis is the predicted probability of immunological remission based on the predictive model. The line adjacent to the ideal line represents the predictive accuracy.

Figure 6 Calibration curves of the nomogram in the training and validation datasets. The y-axis indicates the observed cumulative incidence for immunological remission, and the x-axis is the predicted probability of immunological remission based on the predictive model. The line adjacent to the ideal line represents the predictive accuracy.

Figure 7 Decision curve analysis plot of the nomogram in the training and validation datasets. Red line represents the clinical net benefits according to the threshold probabilities; horizontal line assumes no cases will get immunological remission; grey line assumes all cases will get immunological remission.

Figure 7 Decision curve analysis plot of the nomogram in the training and validation datasets. Red line represents the clinical net benefits according to the threshold probabilities; horizontal line assumes no cases will get immunological remission; grey line assumes all cases will get immunological remission.