Potential Role and Prognostic Value of Interleukin-15 for Mortality Among Elderly Patients with Sepsis

Figures & data

Table 1 Comparison of Demographic Data Between the Survival Group and Non-Survival Group

Demographic Data	Survival Group (N=69)	Non-Survival Group (N=151)	P value
Sex, n (%)
Male	43(62.3)	89(58.9)	0.659
Female	26(37.7)	62(41.1)
Age, median (range)	70(60, 83)	75(65, 83)	0.186
SOFA	5(3, 5)	8(6, 10)	<0.001
APACHE2	16(11.5, 18.5)	22(17, 27)	<0.001
Temperature (°C)	36.3(36.0, 36.5)	36.4(36.2, 36.6)	0.39
Heart rate (beats/min)	87(73, 106)	86(74, 101)	0.618
Systolic pressure (mmHg)	140(128.5, 150)	132(115, 144.5)	0.007
Diastolic pressure (mmHg)	75(68, 85)	74(64, 82)	0.185
MAP (mmHg)	101.04±21.98	102.77±25.54	0.78
PaO2 (mmHg)	85.5(67, 104.25)	77.1(65.15, 93)	0.358
PaCO2 (mmHg)	36(32, 40.5)	36(33, 44)	0.193
Lac (mmol/L)	1.15(0.9, 1.63)	1.3(1, 1.98)	0.102
BUN (mmol/L)	6.03(4.26, 8.49)	5.94(4.45, 8.75)	0.901
Cr (µmol/L)	73(53.1, 86.65)	64.9(48.4, 86.7)	0.194
GLU (mmol/L)	7.21(5.36, 10.81)	8.22(6.4, 11.49)	0.136
TBIL (µmol/L)	15(11.08, 21.28)	14.05(9.38, 23.5)	0.474
AST (IU/L)	24.6(18.98, 32.88)	28.25(18.58, 42.03)	0.275
ALT (IU/L)	20(15.53, 27.1)	22.05(16.1, 31.73)	0.359
ALB (g/L)	36.3(30, 41.70)	32.85(24.58, 38)	0.008
Myoglobin (ng/mL)	74.7(55.25, 98.65)	115.55(57.6, 266.43)	0.147
PCT (ng/mL)	0.05(0.05, 1.2)	0.05(0.05, 0.73)	0.864
CRP (mg/L)	23(8, 82)	14(7.75, 68.48)	0.484
Oxygenation index	304.8(189.66, 420.7)	271(181, 344)	0.129
HDL (mmol/L)	1.41(1.06, 1.72)	1.19(0.93, 1.44)	0.021
LDL (mmol/L)	1.99(1.7, 2.7)	2.15(1.52, 2.72)	0.646
WBC (×10^9/L)	8.65(7.2, 11.93)	9(7.3, 11.8)	0.895
PLT (×10^9/L)	213.5(153.5, 302)	176(136, 247.75)	0.032
Lymphocyte (×10^9/L)	1.28(0.84, 2.13)	1.27(0.8, 1.8)	0.726
Monocyte (×10^9/L)	0.5(0.41, 0.79)	0.52(0.37, 0.65)	0.433
Neutrophil (×10^9/L)	6.3(5.1, 11.13)	6.48(4.45, 9.89)	0.529
IL-15 (pg/mL)	1.03(0.7, 1.71)	1.80(1.14, 3.09)	<0.001

Table 2 Multivariate Logistic Regression Analysis of Risk Factors for 28-Day Mortality in Elderly Patients with Sepsis

Factor	β	SE	Wald χ^2	OR	95% Cl	P-value
IL-15	0.611	0.169	13.084	1.842	1.323, 2.565	<0.001
PLT	−0.04	0.002	4.821	0.996	0.992, 1.000	0.028
ALB	−0.053	0.020	7.137	0.949	0.913, 0.986	0.008
Constant	−3.308	0.603	30.091	0.037		<0.001

Table 3 Pearson Correlation Analysis of IL-15 and Other Biomarkers

Variable	IL-15
	r	P
Age	−0.025	0.720
SOFA	0.068	0.320
APACHE II	0.007	0.915
PLT	0.038	0.595
ALB	−0.003	0.965
WBC	0.063	0.374
Lac	0.007	0.923
PCT	0.033	0.66
CRP	−0.034	0.641

Table 4 Receiver Operating Characteristic Curve (ROC) Analysis of the Prognostic Value of IL-15 Together with Other Factors for 28-Day Mortality of Elderly Patients with Sepsis

	AUC	Sensitivity	Specificity	Cut-off	95% CI	P-value
IL-15	0.691	46.67%	85.81%	1.99	0.618, 0.764	<0.001
SOFA	0.842	80.82%	78.88%	5.5	0.786, 0.898	<0.001
APACHE II	0.750	53.38%	91.31%	21.5	0.684, 0.817	<0.001
IL-15+APACHE II	0.828	77.70%	80.59%	0.5829	0.771, 0.885	<0.001
IL-15+SOFA	0.880	80.95%	85.08%	0.6603	0.829, 0.932	<0.001

Figure 1 Analysis of the prognostic value of IL-15 together with other factors for 28-day mortality of elderly patients with sepsis by using ROC curve.

Data Sharing Statement

We declare that all the data in this article are authentic, valid, and available for use on reasonable request. Dr Jingjing Zhao can be contacted ([email protected]) regarding the availability of data and materials.