lncRNA TPRG1-AS1 Screened the Onset of Acute Coronary Syndromes and Predicted Severity and the Occurrence of MACE During Patients’ Hospitalization

Figures & data

Table 1 Baseline Information of Study Subjects

	Normal	ACS	P-value
Age (years)	58.56 ± 9.51	58.42 ± 9.89	0.926
Gender (male/female)	34/32	57/52	0.771
BMI (kg/m^2)	23.98 ± 3.39	24.66 ± 4.21	0.271
Smoking (n, %)	26, 39.39%	48, 44.04%	0.547
Drinking (n, %)	28, 42.42%	44, 40.37%	0.789
Hypertension (n, %)	37, 56.06%	67, 61.47%	0.480
Diabetes (n, %)	11, 16.67%	23, 21.10%	0.472
TC	4.04 ± 0.32	4.12 ± 0.59	0.326
TG	1.75 ± 0.21	1.71 ± 0.24	0.277
LDL	2.35 ± 0.89	2.32 ± 0.93	0.885
HDL	1.24 ± 0.24	1.19 ± 0.18	0.164
Gensini score	4.86 ± 1.14	68.47 ± 12.57	< 0.001
Cys-c	0.81 ± 0.11	1.14 ± 0.29	< 0.001
cTnI	0.003 ± 0.0001	1.19 ± 0.36	< 0.001
NT-proBNP	126.94 ± 48.53	449.93 ± 123.14	< 0.001

Abbreviations: TC, total cholesterol, mmol/L; TG, triglyceride, mmol/L; LDL, low-density lipoprotein, mmol/L; HDL, high-density lipoprotein, mmol/L; Cys-c, cystatin C, mg/L; cTnI, cardiac troponin I, ng/mL; NT-proBNP, N-terminal pro-brain natriuretic peptide, pg/mL.

Figure 1 Expression and significance of TPRG1-AS1 in ACS. (a). TPRG1-AS1 was upregulated in ACS relative to the normal group. (b and c). TPRG1-AS1 was identified as a risk factor for ACS (b) and could discriminate ACS patients from the normal group (c). ****P < 0.0001.

Figure 2 Correlation of serum TPRG1-AS1 levels with the disease severity of ACS patients. TPRG1-AS1 was positively correlated with ACS patients’ Gensini score (r = 0.870, a), cys-C (r = 0.830, b), cTnI (r = 0.888, c), and NT-proBNP (r = 0.838, d).

Table 2 Risk Factors for the Occurrence of MACE Evaluated by Logistic Regression Analysis

	OR	95% CI	P-value
TPRG1-AS	10.343	1.204–88.811	0.033
Genesini score	2.483	0.427–14.431	0.311
Cys-c	1.807	0.541–6.038	0.337
CTnI	2.606	0.644–10.551	0.179
NT-proBNP	1.809	0.506–6.462	0.362

Abbreviations: Cys-c, cystatin C, mg/L; cTnI, cardiac troponin I, ng/mL; NT-proBNP, N-terminal pro-brain natriuretic peptide, pg/mL.

Figure 3 Kaplan-Meier curve of ACS patients based on the serum level of TPRG1-AS1 (the occurrence of MACE was defined as the endpoint). Patients with relatively high TPRG1-AS1 expression showed a high occurrence of MACE than that of patients with relatively low TPRG1-AS1 expression. log rank P = 0.025.