The Association Between S100A12 Protein and C-Reactive Protein with Malignant Ventricular Arrhythmias Following Acute Myocardial Infarction in the Elderly

Figures & data

Table 1 Baseline Characteristics of the Patients

Characteristic	MVA (n=27)^a	No-MVA (n=132)^a	p-value^b
Male n(%)	18 (67)	78 (59)	0.5
Age (year)	68 (63,70)	67 (61,74)	>0.9
Drinking n(%)	6 (22)	24 (18)	0.6
Smoking n(%)	3 (11)	25 (19)	0.4
Cerebral infarction n(%)	3 (11)	23 (17)	0.6
Hypertension n(%)	17 (63)	102 (77)	0.12
Antiplatelet therapy n(%)	4 (15)	24 (18)	0.8
PLT (10^9/L)	201 (153,225)	182 (147,245)	0.6
Monocytes (10^9/L)	0.48 (0.41,0.56)	0.51 (0.40,0.67)	0.4
Lymphocytes (10^9/L)	1.15 (0.91,1.45)	1.46 (1.10,1.91)	0.017
Neutrophils (%)	71 (62,77)	68 (61,75)	0.2
HGB (g/L)	135 (127,147)	138 (128,149)	0.8
WBC (10^9/L)	6.80 (5.65,7.65)	6.85 (5.60,9.00)	0.7
Eosinophils (%)	1.80 (0.40,2.70)	1.65 (0.68,2.73)	>0.9
TC (mmol/L)	4.51 (3.93,5.26)	4.91 (4.23,5.62)	0.11
TG (mmol/L)	1.19 (0.84,1.86)	1.30 (0.95,1.88)	0.4
ApoA1 (g/L)	1.16 (1.04,1.43)	1.21 (1.00,1.40)	0.9
ApoB (g/L)	0.89 (0.71,1.07)	0.98 (0.82,1.15)	0.084
HDL (mmol/L)	1.78 (1.28,2.13)	1.59 (1.33,1.90)	0.5
LDL (mmol/L)	2.60 (2.08,3.02)	2.89 (2.37,3.41)	0.052
Lpa (g/L)	172 (76,525)	185 (110,374)	>0.9
HbA1c (%)	6.60 (5.40,7.75)	6.10 (5.50,7.23)	0.6
VitB12 (pg/mL)	397 (312,588)	465 (315,660)	0.6
Folic acid (ng/mL)	8.9 (4.6,12.8)	6.8 (4.4,10.3)	0.3
T4 (nmol/L)	83 (74,91)	83 (72,101)	0.9
T3 (nmol/L)	1.11 (0.93,1.53)	1.26 (1.02,1.54)	0.2
TSH (uIu/mL)	1.84 (1.16,3.15)	1.79 (0.98,2.90)	0.6
HA (ng/mL)	57 (45,76)	56 (40,72)	0.5
PCT (ng/mL)	0.48 (0.11,3.13)	1.28 (0.13,2.80)	0.6
SOD (U/mL)	142 (102,163)	141 (113,173)	0.5
Hcy (nmol/L)	11 (8,16)	12 (9,17)	0.3
BNP (pg/L)	117 (47,327)	86 (32,253)	0.2
SdLDL-C (mmol/L)	0.99 (0.56,1.65)	1.10 (0.63,1.59)	0.9
S100A12 (ng/mL)	2.13 (1.91,2.33)	1.77 (1.54,2.19)	0.002
CRP (mg/L)	70 (62,86)	50 (31,73)	<0.001

Notes: The normal range of CRP in blood was 0.068–8.2 mg/L; ^an(%) or Median (IQR); ^bPearson’s Chi-squared test or Wilcoxon rank sum test or Fisher’s exact test.

Abbreviations: PLT, platelet; HGB, hemoglobin; WBC, white blood cell; TC, total cholesterol; TG, Triglyceride; ApoA1, apolipoprotein A1; ApoB, apolipoprotein B; HDL, high density lipoprotein; LDL, low density lipoprotein; Lpa, Lipoprotein a; T4, thyroxine; T3, triiodothyronine; TSH, thyroid stimulating hormone; HA, haemagglutination; PCT, procalcitonin; SOD, Super Oxide Dismutase; Hcy, homocysteine; BNP, Brain natriuretic peptide; SdLDL-C, small dense low- density lipopro-tein-C; CRP, C-reactive protein; MVA, malignant ventricular arrhythmias.

Table 2 Results of the Multivariate Logistic Regression Analysis

	95% CI	OR	p-value
S100A12 (ng/mL)	0.01–0.24	0.06	0.001
LDL (mmol/L)	0.37–16.49	2.34	0.38
ApoB (g/L)	0.28–798.39	13.37	0.20
TC (mmol/L)	0.18–2.78	0.71	0.62
CRP (mg/L)	0.93–0.98	0.95	0.001
Lymphocytes (10^9/L)	0.99–6.25	2.37	0.06

Abbreviations: LDL, low density lipoprotein; ApoB, apolipoprotein B; TC, total cholesterol; CRP, C-reactive protein; CI, confidence interval; OR, odds ratio.

Figure 1 Predictive value of S100A12, CRP, and their combined application for MVA.

Abbreviations: CRP, C-reactive protein; MVA, malignant ventricular arrhythmias.

Data Sharing Statement

All data generated or analysed during this study are included in this article. Further enquiries can be directed to the corresponding author.