Circulating levels of monocyte chemoattractant protein-1 and interleukin-7 in women who have undergone bilateral salpingo-oophorectomy

Figures & data

Figure 1 Monocyte chemoattractant protein-1 (McP-1) and interleukin-7 (IL-7) levels in women before and after bilateral salpingo-oophorectomy (BSO).

Note: *P<0.05 versus women with regular menstruation.

Table 1 Clinical characteristics and hormonal data in women with regular menstruation, women in whom less than 5 years had passed since bilateral salpingo-oophorectomy (BSO), and women in whom 5 years or more had passed since their BSO

Characteristic	No BSO	BSO <5 years	BSO ≥5 years	P-valuea
n	51	27	32
Age (years)	47.0 (45.0–49.0)	49.0 (46.0–51.0)	58.5c (54.0–63.3)	<0.001
BMI (kg/m^2)	23.5 (21.3–25.0)	25.2 (23.3–26.0)	23.4 (20.6–24.7)	0.107
Systolic BP (mmHg)	128.6±11.1	130.9±10.1	124.6± 16.0
Diastolic BP (mmHg)	77.1 ±7.1	79.8±2.5	73.7±11.3
LH (Liu/ml)	3.5 (2.3–5.3)	26.3b (20.4–36.2)	21.3b (13.8–27.7)	<0.001
FSH (Liu/ml)	5.5 (4.6–7.2)	79.1b (66.0–105.1)	86.3b (71.9–104.6)	<0.001
Estradiol (pg/mL)	104.0 (71.0–150.0)	21.0b (12.5–29.0)	12.5b (12.5–28.0)	<0.001
Smokers (%)	7.4	6.3	16.7

Notes: Data expressed as median (25%–75%) or average ± standard deviation.

a Kruskal–Wallis rank test

b P<0.01 versus women with regular menstruation

c P<0.01 versus women with regular menstruation and women in whom less than 5 years had passed after BSO.

Abbreviations: BMI, body mass index; BP, blood pressure; LH, luteinizing hormone; FSH, follicle-stimulating hormone.

Table 2 Serum cytokine and chemokine concentrations in women with regular menstruation, women in whom less than 5 years had passed since bilateral salpingo-oophorectomy (BSO), and women in whom 5 years or more had passed since their BSO

Cytokine/Chemokine (pg/mL)	No BSO	BSO <5 years	BSO ≥5 years	P-valuea
IL-1β	0.40 (0.40–0.61)	0.40 (0.40–0.40)	0.40 (0.40–0.40)	0.507
IL-5	0.40 (0.40–0.40)	0.40 (0.40–0.40)	0.40 (0.40–0.40)	0.973
IL-6	1.35 (0.55–2.61)	0.55 (0.55–2.18)	0.55 (0.55–1.74)	0.128
IL-7	4.85 (3.36–7.04)	6.57 (4.49–9.02)	3.36 (2.20–5.57)	0.035
IL-8	21.40 (5.29–112.45)	18.42 (9.08–51.79)	35.35 (13.38–104.43)	0.368
IL-10	0.45 (0.45–0.79)	0.45 (0.45–1.16)	0.45 (0.45–1.10)	0.861
TNF-α	1.50 (1.50–4.55)	1.50 (1.50–6.82)	1.50 (1.50–6.54)	0.864
MIP-1β	174.07 (122.70–246.90)	150.46 (128.60–236.41)	171.29 (112.11–257.48)	0.824
MCP-1	31.35 (23.03–42.58)	42.98b (29.30–55.61)	34.30 (25.79–49.59)	0.085

Notes: Data expressed as median (25%–75%).

a Kruskal–Wallis rank test

b P<0.05 versus women with regular menstruation.

Abbreviations: IL, interleukin; MCP-1, monocyte chemoattractant protein-1; MIP-1β, macrophage inflammatory protein-1 beta; TNF-α, tumor necrosis factor-alpha.

Figure 2 Correlations of monocyte chemoattractant protein-1 (MCP-1) level with follicle-stimulating hormone (FSH) level in women with regular menstruation and women in whom less than 5 years had passed since their bilateral salpingo-oophorectomy.