Neurofibromatosis Type 1: Optimizing Management with a Multidisciplinary Approach

Figures & data

Figure 1 Venn diagram that illustrates the NF expert’s role in a Multidisciplinary NF1 Care Team.

Figure 2 Schematic outlining the necessary specialties to be included when dealing with specific clinical manifestations of NF1. *For optimal management, it is advisable to consult with a NF expert for all these conditions, prior to referral to specialties included above. **Neurosurgery should be considered imperative when addressing skeletal malformations involving the spine.

Table 1 Revised Diagnostic Criteria for NF1, as of 2021

Diagnostic Criteria of NF1
Two or More of the Following:	Criteria:
1	At least six café-au-lait macules (> 5 mm diameter in prepubertal individuals and >15 mm in postpubertal individuals)
2	Freckling in axillary or inguinal regions
3	Optic pathway glioma
4	At least two Lisch nodules (iris hamartomas)
5	At least two neurofibromas of any type, or one plexiform neurofibroma
6	A distinctive osseous lesion (sphenoid dysplasia or tibial pseudoarthrosis)
7	A first-degree relative with NF1