The Effect of Computer-Assisted Cognitive Remediation Therapy on Cognitive Function, Social Function and Quality of Life in Patients with Vascular Dementia

Figures & data

Table 1 Baseline Characteristics of Included Population

Variables	Included Population (N=98)
Male	54 (55.1)
Age, years	62.47±10.23
Duration of vascular dementia, months	14.16±1.27
MMSE score	20.95±2.12
NPI score	67.63±4.89
CDR score	1.16±0.47
Hypertension	72 (73.5)
Diabetes mellitus	5 (5.1)
Dyslipidemia	16 (16.3)
LDL-C, mmol/L	1.92±0.76
HDL-C, mmol/L	1.19±0.35
Total cholesterol, mmol/L	3.54±0.98
Triglycerides, mmol/L	1.01±0.81
Antihypertensive drug	67 (68.4)
Antiglycemic drug	10 (10.2)
Lipid lowering drug	21 (21.4)

Note: Data are expressed as mean ± standard deviation or counts (frequency).

Abbreviations: MMSE, mini-mental state examination; NPI, Norwich patellar instability; CDR, clinical dementia rating; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol.

Table 2 Comparison of Cognitive Function Scores in Patients with Vascular Dementia Before and After Treatment (Scores, )

	Orientation	Numeracy	Verbal Ability	Spatial Ability	Immediate Memory	Short Range Memory	Total Score
Before treatment	3.21±1.21	1.63±0.54	5.07±0.47	0.45±0.13	1.51±0.36	0.87±0.25	19.21±2.03
After treatment	5.60±1.35	2.20±0.79	7.10±0.36	0.78±0.24	2.42±0.53	1.17±0.28	23.36±2.98
T Value	13.05	5.89	33.94	11.97	14.06	7.91	11.39
P value	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001

Note: Data are expressed as mean ± standard deviation.

Figure 1 Scatter plot of MMSE total score before and after the intervention of CCRT.

Abbreviations: CCRT, Computer-assisted Cognitive Remediation Therapy; MMSE, Mini-Mental State Examination.

Table 3 Comparison of Scores for Social Function and Daily Life Ability in Patients with Vascular Dementia Before and After Treatment (Scores, )

	SDSS	PSP	ADL
Before treatment	17.34±2.06	31.52±10.27	40.7±11.19
After treatment	8.23±0.94	81.36±14.23	32.7±12.91
T Value	39.82	28.11	4.64
P value	<0.001	<0.001	<0.001

Note: Data are expressed as mean ± standard deviation.

Abbreviations: SDSS, Social Disability Screening Schedule; PSP, Personal and Social Performance; ADL, Activities of Daily Living.

Table 4 Comparison of Quality of Life Scores in Patients with Vascular Dementia Before and After Treatment (Scores, )

	Physical Health	Mental Health	Social Function	Material Life	Total Score
Before treatment	58.32±7.16	60.11±7.03	59.23±7.06	30.11±4.06	204.30±9.47
After treatment	68.24±7.44	69.75±7.15	69.08±7.43	37.46±4.85	230.79±9.56
T Value	9.51	9.51	9.51	11.50	19.48
P value	<0.001	<0.001	<0.001	<0.001	<0.001

Note: Data are expressed as mean ± standard deviation.