CA125-Associated Activated Partial Thromboplastin Time and Thrombin Time Decrease in Patients with Adenomyosis

Figures & data

Figure 1 Study flow diagram.

Table 1 Patient characteristics among groups

Variables	AM Group (n = 200)	LM Group (n = 240)	Control Group (n=81)	p-Value
Age (years)	43 (39-46)	42 (37-46)	39 (33-45)*	0.001
BMI (kg/m^2)	23.31(21.65-25.61)	23.00(20.93-25.15)	21.72(20.02-24.34)*	0.001
Gravidity	3 (2-4)	2 (1-3)*	2 (1-3)*	<0.001
Abortion	2 (1-3)	1 (0-2)*	1 (0-2)*	<0.001
Menorrhagia (n, %)	93 (46.50%)	41 (17.08%)*	5(6.17%)*	<0.001
Anemia (n, %)	105 (52.50%)	72 (30.00%)*	10 (12.35%)*	<0.001
Hb (g/L)	112.00 (93.00-117.00)	126.00 (108.00-135.00)*	129.00 (121.00-135.00)*	<0.001
Dysmenorrhea(n,%)	175(87.50%)	55 (22.92%)*	15(18.52%)*	<0.001
Uterine size (cm^3)	173.18 (115.05-253.86)	108.44 (71.76-182.89)*	98.80 (78.00-119.37)*	<0.001
CA125(U/mL)	83.05 (51.65-136.75)	16.30 (11.26-20.03)*	13.27 (10.13-18.25)*	<0.001
CA199(U/mL)	15.06 (9.61-25.12)	7.80 (5.69-13.11)*	10.21 (6.77-13.88)*	<0.001

Notes: Data were shown as M (P25-75) and n (%) as appropriate; *p < 0.025 (compared with the AM group). AM group, patients with adenomyosis. LM group, patients with uterine leiomyoma. Control group, patients with cervical intraepithelial neoplasia III.

Abbreviations: BMI, body mass index; Hb, hemoglobin.

Table 2 Comparisons of Coagulation Parameters Between Groups

Parameters	AM Group (n = 200)	LM Group (n = 240)	Control Group (n=81)	p-value
PLT (10^9/L)	296.50 (239.25–351.25)	284.50 (246.00–337.75)	252.00 (213.00–296.00)*	<0.001
PT (s)	11.2(10.80–11.80)	11.20(10.70–11.68)	11.20(10.80–11.70)	0.944
APTT (s)	26.70 (25.30–28.00)	26.75 (25.40–28.50)	27.60 (26.25–28.95)*	0.001
TT (s)	17.70 (17.10–18.40)	17.90 (17.30–18.50)*	18.20 (17.65–18.55)*	0.002
FIB (g/L)	2.63 (2.32–3.01)	2.56 (2.29–2.98)	2.56 (2.17–2.87)	0.080
D-dimer (mg/L)	0.27 (0.22–0.39)	0.24 (0.22–0.32)	0.22 (0.22–0.28)*	<0.001
INR	0.96 (0.91–1.01)	0.96 (0.92–1.02)	0.97 (0.92–1.02)	0.873

Notes: Data were expressed as M (P25-75); *p < 0.025 (compared with AM group). AM group, patients with adenomyosis. LM group, patients with uterine leiomyoma. Control group, patients with cervical intraepithelial neoplasia III.

Abbreviations: PLT, platelet count; PT, plasma prothrombin time; APTT, activated partial thromboplastin time; TT, thrombin time; FIB, fibrinogen; INR, international normalized ratio.

Figure 2 Comparisons of Coagulation Parameters between Groups (median and range). (A)Comparisons of platelet count (PLT) between the three groups. (B) Comparisons of activated partial thromboplastin time (APTT) between the three groups. (C) Comparisons of thrombin time (TT) between the three groups. (D) Comparisons of D-dimer between the three groups. *p < 0.025 (compared with AM group).

Table 3 Correlations of Coagulation Parameters, Characteristics and Adenomyosis

Covariates	Estimates	SE	Odds Ratio (95% CI)	p-value
CA125	5.780	0.651	323.860(90.424–1159.924)	<0.001
PLT	−0.002	0.003	0.998(0.992–1.005)	0.632
PT	0.067	0.495	1.069(0.405–2.820)	0.893
APTT	0.259	0.107	1.295(1.050–1.598)	0.016
FIB	−0.417	0.434	0.659(0.281–1.543)	0.337
TT	−0.443	0.193	0.642(0.439–0.938)	0.022
D-dimer	−0.153	0.320	0.858(0.459–1.606)	0.633
INR	−0.157	3.990	0.855(0.000–2130.248)	0.969
Age	0.258	0.676	1.294(0.344–4.872)	0.703
BMI	1.019	0.567	2.771(0.913–8.411)	0.072
Gravidity	0.632	0.361	1.882(0.927–3.820)	0.080
Abortion	−0.063	0.405	0.939(0.425–2.075)	0.876
Hb	0.466	0.666	1.594(0.432–5.879)	0.484
Uterine size	0.228	0.469	1.256(0.501–3.152)	0.627
CA199	0.536	0.456	1.708(0.698–4.179)	0.241
Menorrhagia	1.996	0.542	7.363(2.544–21.315)	<0.001
Dysmenorrhea	3.117	0.518	22.590(8.185–62.347)	<0.001

Abbreviations: Hb, hemoglobin; PLT, platelet count; PT, plasma prothrombin time; APTT, activated partial thromboplastin time; FIB, fibrinogen; TT, thrombin time; FIB, fibrinogen; INR, international normalized ratio; SE, standard error.

Figure 3 Correlation of APTT and TT with CA125 in Patients with Adenomyosis. (A) Correlation of activated partial thromboplastin time (APTT) with CA125. (B) Correlation of thrombin time (TT) with CA125.

Figure 4 Predictive Value of activated partial thromboplastin time (APTT) and thrombin time (TT) in the Diagnosis of Adenomyosis based on the receiver operating characteristic curve.