Gender Disparities in Psychological Disturbances and Quality of Life Among Adolescent and Adult Patients with Thalassemia: A Review

Figures & data

Figure 1 The flow diagram of study selection in this review.

Table 1 Overview of Studies Examining Gender Disparities in Psychological Disturbance and Quality of Life Among Adolescent and Adult Patients with Thalassemia Listed Chronologically According to Year of Publication

Author	Study design	Country	N	% Female (N)	Endpoint	Impact of Gender
Ansari et al* (2014)^Citation27	Case-control	Iran	250	48.4 (121)	QoL	+
Khairkhah et al* (2015)^Citation28	Cross-sectional	Iran	150	53.3 (80)	QoL	+
Gan et al (2016)^Citation29	Cross-sectional	Malaysia	127	62.2 (79)	QoL	-
Seyedifar et al (2016)^Citation30	Cross-sectional	Iran	512	50.2 (257)	QoL, anxiety, depression	+
Floris et al* (2018)^Citation31	Cross-sectional	Italy	190	49.5 (94)	QoL	+
Maheri et al (2018)^Citation32	Cross-sectional	Iran	389	54.0 (210)	Anxiety, depression	-
Patel et al (2018)^Citation33	Retrospective	United States (US)	10,046	69.6 (6994)	Anxiety, depression	+
Patel et al* (2019)^Citation34	Cross-sectional	Sri Lanka	120	53.6 (74)	QoL, depression	+
Yousif et al (2019)^Citation35	Cross-sectional	Iraq	100	53.0 (53)	Depression	+
Goulas et al (2020)^Citation36	Cross-sectional	Greece	131	56.5 (74)	QoL	-
Rikos et al* (2020)^Citation37	Cross-sectional	Greece	119	52.9 (63)	QoL	+
Hamdy et al (2021)^Citation38	Cross-sectional	Egypt	112	43.8 (49)	QoL	+ (VT)
Khodashenas et al* (2021)^Citation39	Cross-sectional	Iran	100	55.8 (53)	QoL	-
Mardhiyah et al (2022)^Citation40	Cross-sectional	Indonesia	120	45.8 (55)	QoL	-
Sarhan et al* (2022)^Citation41	Cross-sectional	Palestine	163	55.2 (90)	Depression	+
Hossain et al (2023)^Citation42	Cross-sectional	Bangladesh	356	46.0 (163)	QoL	+ (BP, PHS)

Notes: *Gender only used as covariate, VT, vitality (SF-36); BP, bodily pain (SF-36); PHS, physical health summary (SF-36).

Ansari S, Baghersalimi A, Azarkeivan A, Nojomi M, Rad AH. Quality of life in patients with thalassemia major. Iran J Ped Hematol Oncol. 2014;4(2):57–63.

 PubMedGoogle Scholar

Khairkhah F, Nesheli HM, Yahyaei A, Khodabakhsh E, Hosseini SR. Evaluation of mental health and quality of life among β-thalassemia major patients. Caspian J of Pediatr. 2015;1(2):54–59. doi:10.22088/acadpub.BUMS.1.2.54

 Google Scholar

Gan GG, Hue YL, Sathar J. Factors affecting quality of life in adult patients with Thalassaemia major and intermedia. Ann Acad Med Singap. 2016;45(11):520–523.

 PubMed Web of Science ®Google Scholar

Seyedifar M, Dorkoosh FA, Hamidieh AA, et al. Health-related quality of life and health utility values in beta thalassemia major patients receiving different types of iron chelators in Iran. Int J Hematol Oncol Stem Cell Res. 2016;10(4):224–231.

 PubMedGoogle Scholar

Floris F, Comitini F, Leoni G, et al. Quality of life in Sardinian patients with transfusion-dependent thalassemia: a cross-sectional study. Qual Life Res. 2018;27(10):2533–2539. doi:10.1007/s11136-018-1911-7

 PubMed Web of Science ®Google Scholar

Maheri A, Sadeghi R, Shojaeizadeh D, Tol A, Yaseri M, Rohban A. Depression, anxiety, and perceived social support among adults with beta-thalassemia major: cross-sectional study. Korean J Fam Med. 2018;39(2):101–107. doi:10.4082/kjfm.2018.39.2.101

 PubMed Web of Science ®Google Scholar

Patel K, Bhivandkar S, Desai R, Antin T. The burden of psychiatric illnesses in adult patients with beta-thalassemia: a 5-year nationwide inpatient evaluation in the United States. Ann Hematol. 2019;98(4):851–860. doi:10.1007/s00277-018-3557-5

 PubMed Web of Science ®Google Scholar

Patel P, Beamish P, da Silva TL, et al. Examining depression and quality of life in patients with thalassemia in Sri Lanka. Int J Non-Commun Dis. 2019;4:27–33. doi:10.4103/jncd.jncd_49_18

 Google Scholar

Yousif LH, Yacoub SE. Depression in adolescents with beta-thalassemia major in Erbil city-Iraq. Adv Med J. 2019;5(2):12–18. doi:10.56056/amj.2019.93

 Google Scholar

Goulas V, Kouraklis-Symeonidis A, Manousou K, et al. A multicenter cross-sectional study of the quality of life and iron chelation treatment satisfaction of patients with transfusion-dependent β-thalassemia, in routine care settings in Western Greece. Qual Life Res. 2021;30(2):467–477. doi:10.1007/s11136-020-02634-y

 PubMed Web of Science ®Google Scholar

Rikos N, Giannadaki G-K, Spontidaki A, Tzagkaraki M, Linardakis M. Health status, anxiety, depression, and quality of life of patients with thalassemia. J Public Health. 2020;29:1313–1320. doi:10.1007/s10389-020-01241-y

 Google Scholar

Hamdy M, Draz IH, El Sayed IT, Ayyad AAF, Salemd MR. Assessment of quality of life among beta-thalassemia major patients attending the hematology outpatient clinics at Cairo University Hospital. Open Access Maced J Med Sci. 2021;9(E):156–160. doi:10.3889/oamjms.2021.5692

 Google Scholar

Khodashenas M, Mardi P, Taherzadeh-Ghahfarokhi N, Tavakoli-Far B, Jamee M, Ghodrati N. Quality of life and related paraclinical factors in Iranian patients with transfusion-dependent thalassemia. J Environ Public Health. 2021;2021:2849163. doi:10.1155/2021/2849163

 PubMed Web of Science ®Google Scholar

Mardhiyah A, Mediani HS, Panduragan SL, Yosep I, Lindayani L. Hope and quality of life among adolescent with thalassemia: a cross-sectional study in Indonesia. Open Access Maced J Med Sci. 2022;10(G):667–673. doi:10.3889/oamjms.2022.9597

 Google Scholar

Sarhan AL, Modallal S, Mahamid FA, Berte DZ. Depression symptoms and associated factors among thalassemia patients in the Palestinian territories: a cross-sectional study. Middle East Curr Psychiatry. 2022;29:2. doi:10.1186/s43045-021-00166-w

 Google Scholar

Hossain MJ, Islam MW, Munni UR, et al. Health-related quality of life among thalassemia patients in Bangladesh using the SF-36 questionnaire. Sci Rep. 2023;13(1):7734. doi:10.1038/s41598-023-34205-9

 PubMed Web of Science ®Google Scholar