Figures & data
Figure 1 Study design.
Abbreviation: R, randomization.
Table 1 Demographic and baseline characteristics
Table 2 TEAEs occurring in ≥2% of patients in any treatment group, n (%)
Table 3 Occurrence of AE of interest by oral methylnaltrexone dose
Table 4 Drug-related treatment-emergent adverse eventsTable Footnotea occurring in ≥1% of patients in any treatment group, n (%)
Table 5 TEAEs in the cardiac disorder SOC, n (%)
Figure 2 Median daily morphine-equivalent dose (MED) over time.
Figure 3 Mean OOWS scores over time (A) with cramping item and (B) without cramping item.
Notes:
aP<0.05. Minimum possible OOWS score is 0 and the maximum is 13.Citation23
Abbreviation: OOWS, Objective Opioid Withdrawal Scale.
Abbreviation: OOWS, Objective Opioid Withdrawal Scale.
Figure 4 Mean SOWS scores over time (A) with cramping item and (B) without cramping item.
Notes:
aP<0.05. The SOWS consists of 19 items that are rated on a scale of 0–4, where 0 is not at all and 4 is extremely. The minimum score is 0 and the maximum is 76.Citation23
Abbreviation: SOWS, Subjective Opioid Withdrawal Scale.
Abbreviation: SOWS, Subjective Opioid Withdrawal Scale.
Figure 5 Mean pain-intensity scores over time.
Note: Pain rated on an 11-point scale ranging from 0 (none) to 10 (worst pain possible).
