Figures & data
Table 1 European Federation of Neurological Societies Recommended Treatment for Common Neuropathic Pain Conditions
Figure 1 Role of the endocannabinoid system in the control of pain at peripheral, spinal, and supraspinal levels. Cannabinoid receptor activity inhibits the ascending nociceptive transmission, activates the inhibitory descending pathway, and modifies the emotional component of pain. CB1R, Cannabinoid type 1 receptor; CB2R, Cannabinoid type 1 receptor. Reproduced with permission from Maldonado R, Baños JE, Cabañero D. The endocannabinoid system and neuropathic pain. Pain. 2016;157(Suppl 1):S23–S32. Available from: https://insights.ovid.com/article/00006396-201602001-00005.Citation40
![Figure 1 Role of the endocannabinoid system in the control of pain at peripheral, spinal, and supraspinal levels. Cannabinoid receptor activity inhibits the ascending nociceptive transmission, activates the inhibitory descending pathway, and modifies the emotional component of pain. CB1R, Cannabinoid type 1 receptor; CB2R, Cannabinoid type 1 receptor. Reproduced with permission from Maldonado R, Baños JE, Cabañero D. The endocannabinoid system and neuropathic pain. Pain. 2016;157(Suppl 1):S23–S32. Available from: https://insights.ovid.com/article/00006396-201602001-00005.Citation40](/cms/asset/aa183102-50a2-4220-b8fa-a09b57983a1a/djpr_a_12170372_f0001_b.jpg)
Table 2 Randomized Clinical Trials and Extension Studies of THC:CBD Oromucosal Spray (Nabiximols) in Neuropathic Pain
Figure 2 Proportion of patients with chronic pain (neuropathic 62.1%; mixed 31.1%; nociceptive 6.8%) reporting ≥50% improvement from baseline in Aggregated 9-Factor Symptom Relief (ASR-9) scores after 12 weeks’ treatment with THC:CBD oromucosal spray (nabiximols). Data from Ueberall et al (2019).Citation101
Abbreviations: PIX, pain intensity index; mPDI, modified pain disability index; MQHFF, Marburg Questionnaire on Habitual Health Findings; SF12PCS, Short Form 12-item Health Survey physical component score; SF12MCS, Short Form 12-item Health Survey mental component score; DASS, Depression, Anxiety, Stress Scale.
![Figure 2 Proportion of patients with chronic pain (neuropathic 62.1%; mixed 31.1%; nociceptive 6.8%) reporting ≥50% improvement from baseline in Aggregated 9-Factor Symptom Relief (ASR-9) scores after 12 weeks’ treatment with THC:CBD oromucosal spray (nabiximols). Data from Ueberall et al (2019).Citation101Abbreviations: PIX, pain intensity index; mPDI, modified pain disability index; MQHFF, Marburg Questionnaire on Habitual Health Findings; SF12PCS, Short Form 12-item Health Survey physical component score; SF12MCS, Short Form 12-item Health Survey mental component score; DASS, Depression, Anxiety, Stress Scale.](/cms/asset/109f9fae-0462-4d1c-846c-7b59cf369915/djpr_a_12170372_f0002_c.jpg)