Secondary Adrenal Insufficiency and Growth Hormone Deficiency in Patients with Fibromyalgia

Figures & data

Table 1 Summary of Laboratory Data and Dynamic Testing for 22 Patients with Fibromyalgia and Secondary Adrenal Insufficiency

Demographic Data		Baseline Measurements			CST	Insulin Tolerance Test		Imaging	Therapy and Outcomes
Sex	Age (Years)	Cortisol (mcg/dL)	ACTH (pg/mL)	IGF-1 (Z-score)	Peak Cortisol (mcg/dl)	Peak Cortisol (mcg/dl)	Peak GH (ng/mL)	Negative Pituitary MRI	Treatment	Symptom Improvement
F	25	1.1	29	−1.65	16	<1	0.62	Yes	HC	Unknown
F	48	4.2	7.7	1.22	22	5.4	0.05	Yes	HC	Yes
F	37	9.7	12	-	15	5.4	0.73	Yes	HC	No
F	25	6.3	23	−0.84	19	5.7	1.64	No	HC	Yes
M	56	6.9	26	0.67		7.2	3.83	Yes	HC	Unknown
F	22	5.7	12	−1.04	18	7.5	12	Yes	HC	Unknown
F	43	9.4	54	0.13		8.1	0.22	Yes	HC, GH	Unknown
F	61	9.1	13	−1.37	20	8.1	0.15	Yes	HC	Yes
F	39	6.5	14	−1.13	19	8.4	0.27	Yes	HC	Unknown
F	39	8.5	36	1.70		8.5	3.7	Yes	HC	Yes
F	34	11	19	−1.96		10	0.5	Yes	HC, GH	Unknown
F	53	7.3	20	0.84	20	11	0.06	Yes	HC, GH	Yes to HC, no to GH
F	47	9.3	8	–	22	11	4.9	Yes	Pred	No
F	21	11	17	–		11	0.26	Yes	HC	Unknown
M	32	11	10	1.08		11	0.07	Yes	HC	Unknown
F	41	4	8.6	−0.17		12	0.36	Yes	HC	No
M	32	5.7	34	−0.84	26	13	0.03	Yes	HC, GH	Unknown
F	65	6.8	9.6	−1.82	26	14	0.69	Yes	HC	Yes
F	39	11	13	−1.71	14	14	–	Yes	HC	No
F	19	9.1	9.2	−1.04	23	17	1.37	Yes	HC	yes
M	26	8.7	19	−1.82	29	17	0.06	Yes	HC, GH	No to HC, yes to GH
F	25	11	21	–		17	3.68	No	HC	Yes

Abbreviations: CST, cosyntropin stimulation test; HC, hydrocortisone; GH, growth hormone; Pred, prednisone; MRI, magnetic resonance imaging.

Figure 1 Thirteen patients with paradoxical cortisol response to hypoglycemia during Insulin Tolerance Test.