Figures & data
Figure 1 (A) Mean response of the total population (n = 91). (B) Mean response of patients belonging to group 1 (patients with a deterioration of their pain) as determined from the mixture model analysis. (C) Mean response of patients belonging to group 2 (patients with no response to treatment). (D) Mean response of patients belonging to group 3 (patients with an initial drop in NPRS followed by a slow decline towards baseline NPRS). (E) Mean response of patients belonging to group 4 (patients with a reduction in NRPS which is maintained throughout the study period). Values are mean ± SEM.
Table 1 Demographics of patients involved in the analysis
Table 2 Pharmacodynamic parameter estimates
Figure 2 Examples of the data fits of Groups 3 and 4. Best, median and worst fits of NPRS responses belonging to Groups 3 (A, B, and C) and 4 (D, E, and F) are given.
Figure 3 Goodness-of-fit plots of the final pharmacodynamic model. Observed versus population predicted (A) and individual predicted NPRS pain score (B). The black lines are the lines of identity. In the lower panel the conditional weighted residuals versus population predicted NPRS score (C) and time (D) are plotted.
Table 3 Percentage reduction in numerical pain rating score from baseline at week 4 and 12