Analgesic effect of 30% glucose, milk and non-nutritive sucking in neonates

Figures & data

Figure 1 DAN scoring system.

Abbreviation: DAN, Douleur Aiguë Nouveau-né [Newborn Acute Pain].

Table I Epidemiological characteristics of newborn (Mean and range) and Comparison of different groups for the site of sampling the number of attempts and the number of bottles collected

	Group 1 Oral administration of 2 ml of glucose 30% (n = 25)	Group 2 non-nutritive sucking of a teat (n = 25)	Group 3 2 ml of glucose + teat (n = 25)	Group 4 30% glucose + nipple + milk (n = 25)	Group 5 Artificial Milk (n = 25)
Sex M/F	9/16	12/13	9/16	12/13	11/14
mean weight (g)	1820 1270–3900	1780 950–3680	1800 1060–3590	1830 1100–5020	1700 1050–3500
mean Gestational age (weeks of gestation)	34	33	34	33	34
	30–41	28–41	32–41	30–41	28–41
Mean post natal Age (d)	7	10	9	8	6
Average hospital stay (d)	3	5	4	3	3
Report awake/asleep	4/21	2/23	3/22	5/20	3/22
Site of sampling
Radial venous	0	0	0	0	1
Other venous punction	25	25	25	25	24
Numbers of attempts at blood collection
One	22	24	22	24	21
two	3	1	3	1	4

Notes: Group 1, oral administration of 2 mL of glucose 30%; group 2, non-nutritive sucking of a teat; group 3, oral administration of glucose 30% prior to venipuncture, with sucking triggered at the end of administration of glucose and maintained until the end of venipuncture using a nipple; group 4, oral administration of glucose 30%, prior to venipuncture, with sucking triggered at the end of administration of glucose and maintained until the end of venipuncture using a prefilled nipple with age-appropriate milk; group 5, oral administration of age-appropriate milk.

Table 2 DAN scores achieved during venipuncture

	Mean	95% CI	Interquartile range	Median	Minimum, maximum
Group 1	6.16	5.23–7.09	5–8	6	1–10
Group 2	5.24	4.19–6.29	4–7	5	1–10
Group 3	2.56	1.77–3.35	1–4	3	0–6
Group 4	3.80	2.49–5.11	0–6	4	0–10
Group 5	5.80	5.22–6.38	4–6	6	3–8

Abbreviations: CI, confidence interval; DAN, Douleur Aiguë Nouveau-né [Newborn Acute Pain].