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Original Research

Predictors of duloxetine adherence and persistence in patients with fibromyalgia

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Pages 193-201 | Published online: 22 Jun 2012

Figures & data

Table 1 Cohort selection

Table 2 Demographic characteristics among patients with fibromyalgia grouped by adherence to duloxetine over prior year

Table 3 Selected comorbid conditions and use of psychotropic and pain medications among patients with fibromyalgia grouped by adherence to duloxetine over prior year

Table 4 Demographic and pretreatment clinical predictors of patient cohorts with fibromyalgia: multiple logistic regression

Figure 1 (AC) Classification and regression tree analysis for subgroups of adherent and persistent patients with fibromyalgia. (A) Medication possession ratio (MPR): total duloxetine supply days/365. Node size (N) >250. Partition testing: F-test, α = 0.05. (B) Adherence (low, high): adherence = high if MPR ≥ 0.80; adherence = low if MPR < 0.80. Node size (N) >250. Split testing: Pearson χ2, α = 0.05. (C) Duration of therapy (Dur): duration of therapy from the index date to the earliest of either the ending date of the last prescription, the date of the first gap of >15 days between prescriptions, or the end of the study period (12 months). Node size (N) >250. Partition testing: F-test, α = 0.05.

Figure 1 (A–C) Classification and regression tree analysis for subgroups of adherent and persistent patients with fibromyalgia. (A) Medication possession ratio (MPR): total duloxetine supply days/365. Node size (N) >250. Partition testing: F-test, α = 0.05. (B) Adherence (low, high): adherence = high if MPR ≥ 0.80; adherence = low if MPR < 0.80. Node size (N) >250. Split testing: Pearson χ2, α = 0.05. (C) Duration of therapy (Dur): duration of therapy from the index date to the earliest of either the ending date of the last prescription, the date of the first gap of >15 days between prescriptions, or the end of the study period (12 months). Node size (N) >250. Partition testing: F-test, α = 0.05.