Ketamine Assisted Psychotherapy: A Systematic Narrative Review of the Literature

Sandra J Drozdz1 Department of Anesthesia, St. Michael’s Hospital, Toronto, ON, Canada

Akash Goel1 Department of Anesthesia, St. Michael’s Hospital, Toronto, ON, Canada;2 Department of Anesthesiology, Pain and Perioperative Medicine, Stanford University, Stanford, CA, USA;3 Department of Anesthesiology and Pain Medicine, University of Toronto, Toronto, ON, Canada

Matthew W McGarr4 Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada

https://orcid.org/0000-0002-6432-427X

Joel Katz3 Department of Anesthesiology and Pain Medicine, University of Toronto, Toronto, ON, Canada;5 Department of Psychology, York University, Toronto, ON, Canada;6 Department of Anesthesia and Pain Management, University Health Network, Toronto, ON, Canada;7 School of Kinesiology and Health Science, York University, Toronto, ON, Canada

https://orcid.org/0000-0002-8686-447X

Paul Ritvo5 Department of Psychology, York University, Toronto, ON, Canada;7 School of Kinesiology and Health Science, York University, Toronto, ON, Canada

Gabriella F Mattina1 Department of Anesthesia, St. Michael’s Hospital, Toronto, ON, Canada

https://orcid.org/0000-0002-6205-4261

Venkat Bhat8 Interventional Psychiatry Program, St. Michael’s Hospital, Toronto, ON, Canada;9 Department of Psychiatry, University of Toronto, Toronto, ON, Canada;10 Li Ka Shing Knowledge Institute, St. Michael’s Hospital, Toronto, ON, Canada

Calvin Diep3 Department of Anesthesiology and Pain Medicine, University of Toronto, Toronto, ON, Canada

Karim S Ladha1 Department of Anesthesia, St. Michael’s Hospital, Toronto, ON, Canada;3 Department of Anesthesiology and Pain Medicine, University of Toronto, Toronto, ON, Canada;10 Li Ka Shing Knowledge Institute, St. Michael’s Hospital, Toronto, ON, CanadaCorrespondence[email protected]

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Figures & data

Figure 1 PRISMA flowchart of the search and selection processes for included studies.

Notes: Adapted from: Liberati A, Altman DG, Tetzlaff J, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ. 2009;339(jul21 1):b2700–b2700. doi:10.1136/bmj.b2700.^Citation33 Copyright 2009 Liberati et al. Creative Commons.

Figure 2 The distribution of primary and comorbid diagnoses of participants in the KAP studies included for review.

Abbreviations: ADHD, attention deficit hyperactivity disorder; BD, bipolar disorder; EDNOS, eating disorder not otherwise specified; GAD, generalized anxiety disorder; MDD, major depressive disorder; OCD, obsessive compulsive disorder; OIH, opioid-induced hyperalgesia; PTSD, posttraumatic stress disorder; SUD, substance use disorder.

Table 1 Shows the Methods of Ketamine Administration

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Figure 3 Frequency and route of ketamine administration.

Abbreviations: IM, intramuscular; IN, intranasal; IV, intravenous; SL, sublingual.

Table 2 Timing of Psychotherapy in Relation to Ketamine Administration

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Ketamine Assisted Psychotherapy: A Systematic Narrative Review of the Literature

Table 1 Shows the Methods of Ketamine Administration

Table 2 Timing of Psychotherapy in Relation to Ketamine Administration

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Ketamine Assisted Psychotherapy: A Systematic Narrative Review of the Literature

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Table 1 Shows the Methods of Ketamine Administration

Table 2 Timing of Psychotherapy in Relation to Ketamine Administration

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