Figures & data
Figure 1 Potential therapeutic target areas to treat pain that are accessible via HSV-based gene transfer. The illustration represents a primary afferent nociceptor with its receptive field in the periphery and its synapse with a projection neuron in the dorsal horn of the spinal cord. HSV-based gene transfer can be used to interfere with pain processing at many locations along this route. Specific targets (shown in bold) that have been demonstrated to decrease nociceptive responses in animal models of pain are shown for each location.
Abbreviations: GlyR, glycine receptor; TRPV1, transient receptor potential vanilloid type 1; PKC, protein kinase C; NaV, voltage-gated sodium channel; ZFP, zinc finger protein transcription factor; ENK, enkephalin; END, endomorphin; GABA, gamma aminobutyric acid; IL-4, interleukin-4; IL-10, interleukin-10; TNFαSR, tumor necrosis factor alpha soluble receptor; HSV, herpes simplex virus; PAN, primary afferent nociceptor; PNS, peripheral nervous system; CNS, central nervous system; NTs, neurotransmitters.
