Treatment of uncomplicated hemorrhoids with a Hemor-Rite® cryotherapy device: a randomized, prospective, comparative study

Figures & data

Figure 1 The Hemor-Rite® cryotherapy device (Med-Rite Laboratories, Dallas, TX, USA).

Figure 2 Day-by-day pain comparison of the various treatments used.

Note: *Med-Rite Laboratories, Dallas, TX, USA.

Figure 3 Day-by-day pain comparison of the different treatments used in the three applications per day.

Note: *Med-Rite Laboratories, Dallas, TX, USA.

Figure 4 Final pain score for the three treatment alternatives.

Note: *Med-Rite Laboratories, Dallas, TX, USA.

Table 1 Size of the effect per treatment group and sex

	Mean	Standard deviation
Treatment
Hemor-Rite® cryotherapy device*	0.71	0.24
Proctology ointment	0.89	0.19
Placebo	1.47	0.18
Sex
Male	0.83	0.18
Female	1.21	0.19

Note:

* Med-Rite Laboratories, Dallas, TX, USA.

Table 2 Size of the effect corresponding to treatment group and sex

	Size of the effect (difference in marginal means)
Treatment
Hemor-Rite® cryotherapy device* versus placebo	−0.73
Proctology ointment versus placebo	−0.59
Sex
Male versus female	0.35

Note:

* Med-Rite Laboratories, Dallas, TX, USA.

Table 3 The estimated probabilities of moderate to severe bleeding for the three treatment groups

	OR	P-value
Treatment
Proctology ointment versus Hemor-Rite®*	6.31	0.002
Placebo versus Hemor-Rite®*	6.47	0.001
Day
2 versus 1	1.17	0.732
3 versus 1	0.36	0.097
4 versus 1	0.30	0.049
5 versus 1	0.09	0.001
6 versus 1	0.19	0.021
Application
2 versus 1	0.49	<0.001
3 versus 1	0.37	<0.001

Note:

* Med-Rite Laboratories, Dallas, TX, USA.

Abbreviation: OR, Odd ratio.

Table 4 The probabilities of moderate to severe bleeding for the three treatment groups with a confidence interval of 95%

Treatment	Estimated probability	95% confidence interval
Hemor-Rite®*	0.082	0.025	0.140
Proctology ointment	0.400	0.299	0.503
Placebo	0.433	0.356	0.511

Note:

* Med-Rite Laboratories, Dallas, TX, USA.

Figure 5 Probability of moderate or severe bleeding by treatment group (95% confidence interval).

Note: *Med-Rite Laboratories, Dallas, TX, USA.