Management of knee osteoarthritis by combined stromal vascular fraction cell therapy, platelet-rich plasma, and musculoskeletal exercises: a case series

Figures & data

Figure 1 Functional assessment of the knee by the “Stair Climbing Test” over 12 months.

Notes: A 9-step “Stair Climbing Test” assessed monthly by the ability to ascend and descend a flight of stairs, as well as lower extremity strength, power, and balance. The rate of perceived exertion scale (0–10) was used to indicate physical strain, with 10 being the most difficult and 0 being the easiest. C4 – left knee data was not provided as the knee was normal and untreated.
Abbreviations: C1, Case 1; C2, Case 2; C3, Case 3; C4, Case 4.

Figure 2 Functional assessment of the knee by the “Get-Up and Go” test over 12 months.

Notes: A “Get-Up and Go” test was assessed monthly by the subject rising from a chair, walking 3 m, turning around, and returning to the chair to sit down. The rate of perceived exertion scale (0–10) was used to indicate physical strain, with 10 being the most difficult and 0 being the easiest. C4 – left knee data was not provided as the knee was normal and untreated.
Abbreviations: C1, Case 1; C2, Case 2; C3, Case 3; C4, Case 4.

Table 1 Effect of combinatorial treatment on KOOS subscale scores for Case 1

KOOS subscales	Left knee							Right knee
	Pretreatment	Posttreatment (months)						Pretreatment	Posttreatment (months)
		2	3	6	8	10	12		2	3	6	8	10	12
Pain	81	75	100	94	100	100	100	75	64	100	100	100	100	100
Symptoms	86	86	96	93	96	100	100	79	82	86	86	96	96	96
ADL	59	59	100	97	100	100	100	71	65	100	100	100	100	100
Function in Sport/Rec	50	60	100	85	95	95	100	45	35	100	100	100	100	100
Knee-related QOL	0	0	38	63	81	100	100	31	25	38	100	100	100	100

Notes: Effect of combinatorial treatment on Case 1 KOOS subscales. Mean KOOS subscale scores for pretreatment and posttreatment 2, 3, 6, 8, 10, and 12 months for Pain, Symptoms, ADL, Function in Sport/Rec, and knee-related QOL. Table data represent transformed raw scale scores to a 0–100 scale, where 0= extreme knee problem and 100= no knee problem.

Abbreviations: KOOS, Knee Injury and Osteoarthritis Outcome Score; ADL, Activities of Daily Living; Sport/Rec, Sport and Recreation; QOL, Quality of Life.

Table 2 Effect of combinatorial treatment on KOOS subscale scores for Case 2

KOOS subscales	Left knee							Right knee
	Pretreatment	Posttreatment (months)						Pretreatment	Posttreatment (months)
		2	3	6	8	10	12		2	3	6	8	10	12
Pain	56	67	100	100	100	100	100	56	67	78	100	78	89	97
Symptoms	25	57	96	100	100	100	100	25	57	54	79	68	75	86
ADL	74	76	100	100	100	100	100	74	76	85	99	88	97	100
Function in Sport/Rec	15	35	75	100	100	100	100	15	35	55	75	75	90	85
Knee-related QOL	50	69	94	100	100	100	100	50	69	69	81	100	94	94

Notes: Effect of combinatorial treatment on Case 2 KOOS subscales. Mean KOOS subscale scores for pretreatment and posttreatment 2, 3, 6, 8, 10, and 12 months for Pain, Symptoms, ADL, Function in Sport/Rec, and QOL. Table data represent transformed raw scale scores to a 0–100 scale, where 0= extreme knee problem and 100= no knee problem.

Abbreviations: KOOS, Knee Injury and Osteoarthritis Outcome Score; ADL, Activities of Daily Living; Sport/Rec, Sport and Recreation; QOL, Quality of Life.

Table 3 Effect of combinatorial treatment on KOOS subscale scores for Case 3

KOOS subscales	Left knee							Right knee
	Pretreatment	Posttreatment (months)						Pretreatment	Posttreatment (months)
		2	3	6	8	10	12		2	3	6	8	10	12
Pain	28	64	58	89	100	100	100	36	67	56	83	100	100	100
Symptoms	43	68	68	79	100	100	100	43	68	64	75	96	96	100
ADL	34	65	62	87	99	99	99	40	57	53	87	99	99	99
Function in Sport/Rec	10	30	75	50	60	60	60	10	30	45	50	60	60	60
Knee-related QOL	13	44	63	50	81	81	94	19	44	50	44	81	81	94

Notes: Effect of combinatorial treatment on Case 3 KOOS subscales. Mean KOOS subscale scores for pretreatment and posttreatment 2, 3, 6, 8, 10, and 12 months for Pain, Symptoms, ADL, Function in Sport/Rec, and QOL. Table data represent transformed raw scale scores to a 0–100 scale, where 0= extreme knee problem and 100= no knee problem.

Abbreviations: KOOS, Knee Injury and Osteoarthritis Outcome Score; ADL, Activities of Daily Living; Sport/Rec, Sport and Recreation; QOL, Quality of Life.

Table 4 Effect of combinatorial treatment on KOOS subscale scores for Case 4

KOOS Subscales	Right knee
	Pretreatment	Posttreatment (months)
		2	3	6	8	10	12
Pain	64	67	92	92	94	100	100
Symptoms	21	61	79	96	89	96	100
ADL	81	96	97	100	99	100	100
Function in Sport/Rec	10	50	80	100	90	100	100
Knee-related QOL	25	63	63	94	75	94	100

Notes: Effect of combinatorial treatment on Case 4 KOOS subscales. Mean KOOS subscale scores for pretreatment and posttreatment 2, 3, 6, 8, 10, and 12 months for Pain, Symptoms, ADL, Function in Sport/Rec, and QOL. Table data represents transformed raw scale scores to a 0–100 scale, where 0= extreme knee problem and 100= no knee problem.

Abbreviations: KOOS, Knee Injury and Osteoarthritis Outcome Score; ADL, Activities of Daily Living; Sport/Rec, Sport and Recreation; QOL, Quality of Life.