Review of lung sealant technologies for lung volume reduction in pulmonary disease

Figures & data

Figure 1 Photomicrographs of emphysematous lung parenchyma showing hyperdistension of alveolar ducts, increased number and size of alveolar fenestrae with marked destruction of alveolar septa (H&E) ×100 increased (by courtesy of Dr Jelena Stojsic).

Figure 2 CT of a patient with emphysema with giant bulla.

Note: Chest HRCT of 71-year-old man with stable COPD (GOLD III) showing multiple areas of decreased attenuation bilaterally, (hematoxylin-eosin, original magnification ×100).
Abbreviations: CT, computed tomography; HRCT, high-resolution CT; GOLD, Global Initiative on Obstructive Lung Disease.

Figure 3 Lung density histogram in 71-year-old man with stable COPD (GOLD III).

Note: Lung density index was 58.0% for right lung and 62.7% for left lung.
Abbreviation: GOLD, Global Initiative on Obstructive Lung Disease.

Table 1 Common inclusion and exclusion criteria for Bio-BLVR^2,11,25,28,9

Inclusion criteria for Bio-BLVR	Relative exclusion criteria for Bio-BLVR
Advanced single (upper) lobe predominant emphysema^Citation25,Citation28	Heterogenous “scattered distribution” of emphysema
Homogenous emphysema^Citation11	Absence of clinically significant pulmonary hypertension
Heterogenous emphysema (GOLD stage III)^Citation29

Abbreviations: Bio-BLVR, biological bronchoscopic²⁹ lung volume reduction; GOLD, Global Initiative on Obstructive Lung Disease.

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