Novel uterine lavage system for recovery of human embryos fertilized and matured in vivo

Figures & data

Figure 1 Current generation catheter.

Figure 2 Catheter tip close up.

Figure 3 Optimal catheter position intra lavage.

Figure 4 Catheter tip resting against anterior wall intra lavage.

Table 1 Subject characteristics

Number of stimulated cycles	134
Number of unique subjects	81
Average age	26.3±5.3
Average BMI	25.6±4.6
Obstetrical/gynecologic history	54.3% Multiparous (44/81) 45.7% Nulliparous (37/81)
Subject profile	86.4% Egg donors (70/81) 13.6% Pregnancy subjects (11/81)

Figure 5 Recovery efficiency by the cohort.

Table 2 IVF and uterine lavage procedure attributes

IVF procedure attribute	IVF	Uterine lavage
Superovulation with fertility drugs	Required	Optional – natural cycles can be performed
Aspiration of oocytes (unfertilized eggs) from the ovaries	Required – needle inserted transvaginally to retrieve oocytes from the ovaries	Not required
In vitro fertilization (external fertilization of eggs)	Required	Not required – natural fertilization
In vitro culture	Required	Not required – naturally fertilized embryos recovered at lavage after in vivo culture
Embryo biopsy	Optional	Optional
Embryo cryopreservation	Optional	Optional
Preimplantation genetic testing (PGT)	Optional	Optional
Embryo transfer	Optional	Optional