The clinical utility of FibroScan^® as a noninvasive diagnostic test for liver disease

Figures & data

Table 1 Type of liver disease and characteristics of transient elastography for identifying significant fibrosis (METAVIR F≥2)

Liver disease	Study	# patients	% METAVIR F=4	Cutoff (kPa)	Sens	Spec	PPV	NPV	AUROC
HCV	Cardoso et al^Citation48	363	54%	≥7.1	0.68	0.89	0.88	0.70	0.86
HBV	Cardoso et al^Citation48	202	42%	≥7.2	0.74	0.88	0.82	0.82	0.86
PBC	Corpechot et al^Citation50	103	21%	8.8	0.67	1.00	1.00	0.75	0.91
PSC	Corpechot et al^Citation51	66	26%	8.6	0.72	0.89	0.85	0.78	0.84
NAFLD	Gaia et al^Citation52	72	22.2%	7	0.76	0.80	0.75	0.78	0.80
HCV + HIV	Vergara et al^Citation41	169	62%	7.2	0.88	0.66	0.75	0.88	0.83

Abbreviations: AUROC, area under the receiver operator curve; HBV, hepatitis B virus; HCV, hepatitis C virus; HIV, human immunodeficiency virus; NAFLD, nonalcoholic fatty liver disease; NPV, negative predictive value; PBC, primary biliary cirrhosis; PPV, positive predictive value; PSC, primary sclerosing cholangitis; Sens, sensitivity; Spec, specificity.

Table 2 Type of liver disease and characteristics of transient elastography for identifying cirrhosis (METAVIR F=4)

Liver disease	Study	# patients	% METAVIR F=4	Cutoff (kPa)	Sens	Spec	PPV	NPV	AUROC
HCV	Cardoso et al^Citation48	363	9%	≥12.5	0.84	0.94	0.58	0.98	0.93
HBV	Cardoso et al^Citation48	202	8%	≥11	0.75	0.90	0.39	0.98	0.94
PBC	Corpechot et al^Citation50	103	14.5%	16.9	0.93	0.99	0.93	0.99	0.99
PSC	Corpechot et al^Citation51	66	14%	14.3	1.00	0.88	0.56	1.00	0.95
NAFLD	Gaia et al^Citation52	72	12.5%	10.5	0.78	0.96	0.70	0.97	0.94
HCV + HIV	Vergara et al^Citation41	169	15%	14.6	0.91	0.88	0.83	0.94	0.94

Abbreviations: AUROC, area under the receiver operator curve; HBV, hepatitis B virus; HCV, hepatitis C virus; HIV, human immunodeficiency virus; NAFLD, nonalcoholic fatty liver disease; NPV, negative predictive value; PBC, primary biliary cirrhosis; PPV, positive predictive value; PSC, primary sclerosing cholangitis; Sens, sensitivity; Spec, specificity.

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