Are matrix metalloproteinases and their inhibitors reliable diagnosis biomarkers and attractive therapeutic targets in endometriosis?

Figures & data

Figure 1 Comparison of eutopic MMP and TIMP expression between EM and non-EM patients.

Notes: Values from selected MMP and TIMP probe sets were retrieved from Gene Expression Omnibus Database entry GSE51981 and were grouped according to phases of the menstrual cycle and type and stage of the disease. Data are presented as mean ± SD. For more information about the experimental procedure, refer to Gene Expression Omnibus. Available from: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE51981. Accessed July 25, 2016,¹²¹ data from Tamaresis et al.⁵⁶

Abbrevations: UNE, uterine/pelvic disease, no EM; NUNE, no uterine/pelvic disease, no EM; LSE, low stage EM; HSE, high stage EM; PE, proliferative endometrium; ESE, early secretory endometrium; MSE, mid-secretory endometrium; MMPs, matrix metalloproteinases; TIMPs, tissue inhibitors of metalloproteinases; SD, standard deviation.

Figure 2 Comparison of individual MMP and TIMP expression profiles.

Notes: Values from selected MMP and TIMP probe sets were retrieved from Gene Expression Omnibus Database entry GSE51981, and were grouped by patient identification (represented by different colors) to allow comparison of individual expression profiles and highlight remarkable values regardless of the disease or of the cycle phase.

Abbreviations: MMPs, matrix metalloproteinases; TIMPs, tissue inhibitors of metalloproteinases.

Gene Expression Omnibus. Available from: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE51981. Accessed July 25, 2016.

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Tamaresis JS, Irwin JC, Goldfien GA, et al. Molecular classification of endometriosis and disease stage using high-dimensional genomic data. Endocrinology. 2014;155(12):4986–4999.

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