Metalloproteinases in the pathogenesis and progression of metabolic syndrome: potential targets for improved outcomes

Figures & data

Figure 1 Relationship between MS, obesity and NAFLD, and MMPs/TIMPs balance.

Notes: MS is characterized by abdominal obesity and NAFLD. During the expansion of adipose tissue, there is an increase in the secretion of adipokines leading to an imbalance in MMP/TIMPs, which in turn promotes ECM degradation. In NAFLD, the increased expression of TIMPs and concomitantly the reduced activity of MMPs result in protein accumulation in the extracellular space and fibrosis. There is an evidence of the effect of tetracyclines, metformin, and thiazolidinediones on the activity of MMPs and TIMPs.
Abbreviations: MS, metabolic syndrome; NAFLD, nonalcoholic fatty liver disease; MMPs, matrix metalloproteinases; TIMP, tissue inhibitor of metalloproteinase; ECM, extracellular matrix.