Altered intrinsic regional brain spontaneous activity in patients with comitant strabismus: a resting-state functional MRI study

Figures & data

Table 1 Demographic information and clinical measures for Stra and HCs

Condition	Stra	HCs	t	P-valuesa
Male/female	10/10	10/10	N/A
Age (years)	29.50±9.21	28.45±8.15	0.382	0.705
Weight (kg)	59.00±6.37	58.60±5.26	0.758	0.453
Handedness	20R	20R	N/A	>0.99
Duration of strabismus (years)	29.50±9.21	N/A	N/A	N/A
Best-corrected VA–right	1.08±0.19	1.03±0.12	1.121	0.316
Best-corrected VA–left	1.10±0.17	1.08±0.16	−0.381	0.705

Note:

a Independent Student’s t-test.

Abbreviations: HCs, healthy controls; N/A, not applicable; Stra, strabismus; VA, visual acuity.

Figure 1 Significant differences in ReHo values between the Stra group and HCs.

Notes: The brain regions with different ReHo values are the RITC/RFG/RCAL (A), RLG (B), and BCG (C). The red areas denote higher ReHo brain regions. Multiple comparisons were performed using Gaussian random field theory (z >2.3, clusterwise P<0.05 corrected). T-values indicates the results of independent t-tests comparing the two groups in ReHo values in different brain regions.
Abbreviations: BCG, bilateral cingulate gyrus; HCs, healthy controls; RCAL, right cerebellum anterior lobe; ReHo, regional homogeneity; RFG, right fusiform gyrus; RITC, right inferior temporal cortex; RLG, right lingual gyrus; Stra, strabismus.

Figure 2 Mean of altered ReHo values between the Stra group and HCs.

Abbreviations: BCG, bilateral cingulate gyrus; HCs, healthy controls; RCAL, right cerebellum anterior lobe; ReHo, regional homogeneity; RFG, right fusiform gyrus; RITC, right inferior temporal cortex; RLG, right lingual gyrus; Stra, strabismus.

Table 2 Brain regions with significantly different ReHo values between the Stra and HCs

ReHo, Stra > HC	Stra group and HCs				MNI coordinates
	Brain areas	BA	Peak T-values	Voxels	x	y	z
a	RITC/RFG/RCAL	37	5.555	246	48	−54	−21
b	RLG	18	3.344	37	0	−69	−30
c	BCG	19.39	4.247	215	3	−42	48

Note: The statistical threshold was set at the voxel with P<0.05 for multiple comparisons using Gaussian random field theory (z >2.3, clusterwise P<0.05 corrected).

Abbreviations: BA, Brodmann area; HCs, healthy controls; MNI, Montreal Neurological Institute; Stra, strabismus; ReHo, regional homogeneity; RITC, right inferior temporal cortex; RFG, right fusiform gyrus; RCAL, right cerebellum anterior lobe; RLG, right lingual gyrus; BCG, bilateral cingulate gyrus.

Figure 3 ROC curve analysis of the mean ReHo signal values for altered brain regions.

Notes: The area under the ROC curve was 0.938 (P<0.001; 95% CI: 0.864–1) for the RITC/RFG/RCAL (A), and 0.940 (P<0.001; 95% CI 0.870–1) for the BCG (B).
Abbreviations: BCG, bilateral cingulate gyrus; CI, confidence interval; RCAL, right cerebellum anterior lobe; ReHo, regional homogeneity; RFG, right fusiform gyrus; RITC, right inferior temporal cortex; ROC, receiver operating characteristic.