Figures & data
Figure 1 Effects of 12 weeks’ treatment on sleep latency, night-time awakenings, and total sleep time.
Notes: (A) Mean sleep latency at BL and after 12 weeks of treatment with levodopa or levodopa + rasagiline. Sleep latency was assessed using patient sleep diaries. *P=0.003 vs BL, **P<0.001 vs BL; ***P<0.001 vs levodopa alone. (B) Mean number of night-time awakenings at BL and after 12 weeks of treatment with levodopa or levodopa + rasagiline. Night-time awakenings were assessed using patient sleep diaries. *P=0.042 vs BL. (C) Mean total sleep duration at BL and after 12 weeks of treatment with levodopa or levodopa + rasagiline. Total sleep duration was assessed using patient sleep diaries. *P=0.003 vs BL; **P=0.002 vs levodopa alone.
Abbreviation: BL, baseline.
Abbreviation: BL, baseline.
Figure 2 Change from BL in PDSS item scores after 12 weeks of treatment with levodopa or levodopa + rasagiline.
Notes: Overview of PDSS items: 1= overall quality of night’s sleep; 2= difficulty falling asleep each night; 3= difficulty staying asleep; 4= limb restlessness; 5= fidgeting in bed; 6= distressing dreams; 7= distressing hallucinations; 8= nycturia; 9= urine incontinence; 10= limb paresthesia; 11= cramps; 12= limbs painful posturing; 13= tremor; 14= feeling tired and sleepy; 15= daytime sleepiness. *P=0.002 vs levodopa alone.
Abbreviations: BL, baseline; PDSS, Parkinson’s Disease Sleep Scale.
Abbreviations: BL, baseline; PDSS, Parkinson’s Disease Sleep Scale.
Table S1 Baseline characteristics and demographics