Figures & data
Table 1 Patient background and baseline characteristics
Table 2A Time course changes in the number of medications concomitant with lamotrigine
Table 2B Time course changes in the mean dose of medications concomitant with lamotrigine
Table 3 Clinical Global Impressions Improvement scale scores at week 52/withdrawal
Figure 1 Time course changes in adherence to lamotrigine treatment.
Notes: Kaplan–Meier curves showing adherence to lamotrigine treatment for all patients (n=455; A) and for each disease type (B). The rate for all patients was sustained at 39.6% from 637 days (1.74 years) onward with a median duration of 399 days (1.1 years). The first 25% of the patients withdrew within 28 days (4 weeks), with no withdrawals after 637 days. The bipolar I rate was sustained at 51.2% from 602 days (1.6 years) onward, and so the median duration could not be calculated; the longest duration was 1,359 days (3.7 years). The first 25% of the patients withdrew within 40 days (5.7 weeks). The bipolar II rate was sustained at 41.4% from 637 days (1.7 years) onward with a median duration of 340 days (0.93 years) and with the longest duration being 1,211 days (3.3 years). The first 25% of the patients withdrew within 21 days (3 weeks). The bipolar NOS rate was sustained at 36.6% from 586 days (1.60 years) onward with a median duration of 373 days (1.0 year) and the longest duration being 988 days (2.7 years). The first 25% of the patients withdrew within 28 days (4 weeks). Although the curves differ considerably in appearance, no statistically significant differences were observed between them (P=0.45, log-rank test).
Abbreviation: NOS, not otherwise specified.
Abbreviation: NOS, not otherwise specified.
Table 4 Time course changes in HSDS and HSAS scores with and without antidepressants
Table 5 Adverse events experienced by the patients