Rapid infusion of esketamine for unipolar and bipolar depression: a retrospective chart review

Figures & data

Table 1 General clinical and epidemiological characteristics of the patient sample undergoing treatment with rapid infusion of esket amine

Variables	Mean (min–max)
Age	51.0 (42.0–64.0)
Years of education	15.0 (15.0–16.0)
	N (%)
Civil status
Single	7 (25.0)
Married	14 (50.0)
Divorced	3 (10.7)
Widow	2 (7.1)
Male sex	17 (60.7)
Ethnicity (self-declared)
Caucasian	13 (46.4)
Afro-Brazilian	13 (46.4)
Nondeclared	2 (7.2)
Occupation
Student	1 (3.6)
Remunerated occupation	15 (53.6)
Nonremunerated occupation	12 (42.8)
Main diagnosis
Depression unipolar	22 (78.6)
Depression bipolar	6 (21.4)
Psychiatric comorbidities
OCD	4 (14.3)
Social phobia	4 (14.3)
PTSD	2 (7.1)
GAD	2 (7.1)
Panic disorder	2 (7.1)
ADHD	2 (7.1)
Agoraphobia	1 (3.6)
Benzodiazepine use	13 (46.4)
Clinical comorbidities
Cardiovascular disease	7 (25.0)
Endocrine disease	5 (17.9)
Cancer	1 (3.6)

Abbreviations: OCD, obsessive compulsive disorder; PTSD, posttraumatic stress disorder; GAD, generalized anxiety disorder; ADHD, attention-deficit hyperactivity disorder.

Figure 1 Temporal evolution of therapeutic remission of the patient sample upon rapid infusion esketamine treatment.

Note: Points represent means, and error bars show 95% confidence intervals estimated from standard errors.
Abbreviation: MADRS, Montgomery–Åsberg Depression Rating Scale.

Table 2 Summary statistics of depressive and CGI scores evolution of the patient sample on rapid infusion esketamine treatment

Time	Remission n (%)	Therapeutic response n (%)	MADRS			CGI
			Mean (±SD)	Median (IQR)	Min/Max	Mean (±SD)	Median (IQR)	Min/Max
Before intervention (n=27)	–	–	36.25 (7.58)	34.00 (31.00–40.50)	19.00/56.00	4.74 (0.91)	5.00 (4.00–5.00)	3.00/5.00
24 h (n=26)	11 (40.7)	16 (59.3)	17.44 (14.70)	16.00 (4.25–30.75)	2.00/56.00	–	–	–
72 h (n=23)	10 (37.0)	14 (51.8)	18.65 (15.48)	15.00 (4.00–30.00)	2.00/56.00	–	–	–
7 days (n=23)	10 (37.0)	13 (48.1)	19.00 (14.26)	16.00 (6.00–30.00)	2.00/56.00	2.43 (1.44)	2.00 (1.00–4.00)	1.00/5.00

Note: Number differences are due to losses in follow-up.

Abbreviations: CGI, Clinical Global Impression; MADRS, Montgomery–Åsberg Depression Rating Scale; IQR, interquartile range.